Regulation of Eicosanoid Pathways by MicroRNAs

Frontiers in Pharmacology
Meike J SaulBeatrix Suess

Abstract

Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis.

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Citations

Dec 18, 2019·Molecular Genetics & Genomic Medicine·Xiaopeng CaiFang Yu
Nov 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stella UebbingDieter Steinhilber
Feb 24, 2020·International Immunopharmacology·Palani DineshMahaboobkhan Rasool
May 18, 2021·Frontiers in Pediatrics·Zhi LiuDongchi Zhao
Sep 14, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Constanze A JakwerthUlrich M Zissler
Nov 26, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Dengbao LiFangmin Chen

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