Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium.

American Journal of Physiology. Cell Physiology
Sung Huhn KimDaniel C Marcus

Abstract

Reissner's membrane epithelium forms much of the barrier that produces and sustains the large ionic differences between cochlear endolymph and perilymph. We have reported that Reissner's membrane contributes to normal cochlear function by absorbing Na(+) from endolymph via amiloride-sensitive channels in gerbil inner ear. We used mouse Reissner's membrane to 1) identify candidate genes involved in the Na(+) transport pathway, 2) determine whether their level of expression was regulated by the synthetic glucocorticoid dexamethasone, and 3) obtain functional evidence for the physiological importance of these genes. Transcripts were present for alpha-, beta-, and gamma-subunits of epithelial Na(+) channel (ENaC); corticosteroid receptors GR (glucocorticoid receptor) and MR (mineralocorticoid receptor); GR agonist regulator 11beta-hydroxysteroid dehydrogenase (HSD) type 1 (11beta-HSD1); Na(+) transport control components SGK1, Nedd4-2, and WNKs; and K(+) channels and Na(+)-K(+)-ATPase. Expression of the MR agonist regulator 11beta-HSD2 was not detected. Dexamethasone upregulated transcripts for alpha- and beta-subunits of ENaC ( approximately 6- and approximately 3-fold), KCNK1 ( approximately 3-fold), 11beta-HSD1 ( approximately 2...Continue Reading

References

Jul 1, 1978·Acta Oto-laryngologica·T KonishiP J Walsh
Jul 1, 1977·The Annals of Otology, Rhinology, and Laryngology·H Silverstein, T Takeda
Apr 22, 1992·Proceedings. Biological Sciences·E Vega-Saenz de MieraB Rudy
Jan 1, 1989·Connective Tissue Research·J B LianV Shalhoub
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P Gil-Loyzaga, R Pujol
Jan 1, 1988·European Journal of Clinical Pharmacology·R KoopmansC J van Boxtel
Feb 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F M BalisD G Poplack
Jan 1, 1984·Acta Oto-laryngologica. Supplementum·C MorgensternH Amano
Aug 1, 1982·The American Journal of Physiology·O SterkersC Amiel
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·N KizerK Hruska
Jun 1, 1997·The Journal of General Physiology·C M McNicholas, C M Canessa
Oct 6, 1998·The Journal of General Physiology·G K Fyfe, C M Canessa
Aug 19, 1999·Hearing Research·D C Marcus, T Chiba
Mar 11, 2000·British Journal of Pharmacology·J K HadleyD A Brown
Nov 28, 2000·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·C BöhmerF Wehner
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·A DagenaisY Berthiaume
Jan 22, 2002·The Laryngoscope·D M BarrsJ T McElveen
Mar 7, 2002·American Journal of Physiology. Renal Physiology·James D Stockand
May 15, 2002·Audiology & Neuro-otology·Jun Ho Lee, Daniel C Marcus
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark S CooperPaul M Stewart
Nov 8, 2002·Biochimica Et Biophysica Acta·Anthony D O'ConnellMalcolm Hunter
May 20, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hong HaoDavid H Ingbar
May 24, 2003·Neuroscience·J H Lee, D C Marcus
Mar 5, 2004·American Journal of Physiology. Renal Physiology·Satyanarayana R PondugulaDaniel C Marcus
Dec 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anikó Náray-Fejes-TóthGéza Fejes-Tóth
Apr 12, 2005·Cell·Sindhu RajanSteve A N Goldstein
Jul 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bing-e XuMelanie H Cobb
Sep 10, 2005·Endocrinology·Peter M Snyder
Sep 24, 2005·Internal Medicine Journal·P Gates
Oct 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael J MortonMalcolm Hunter
Dec 24, 2005·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Katsumi DoiTakeshi Kubo
Dec 13, 2006·Biochemical and Biophysical Research Communications·Susanne UllrichFlorian Lang
Feb 21, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Dirk HeitzmannRichard Warth
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Aaron M RingRichard P Lifton
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Aaron M RingRichard P Lifton

❮ Previous
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Citations

Jul 9, 2009·Current Opinion in Nephrology and Hypertension·Florian LangVolker Vallon
Aug 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Dennis R Trune
Jan 21, 2011·Physiological Reviews·James A McCormick, David H Ellison
Feb 3, 2011·BMC Physiology·Muneharu YamazakiDaniel C Marcus
Sep 15, 2011·BMC Research Notes·Muneharu YamazakiDaniel C Marcus
Dec 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sung Huhn Kim, Daniel C Marcus
Feb 9, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yang Dong, Jian-Rong Shi
Aug 17, 2010·Audiological Medicine·Mohamed A HamidMayank B Dutia
May 25, 2012·Acta Oto-laryngologica·Jae Chul YooJun Ho Lee
Aug 31, 2010·Journal of Neuroimmunology·Dennis R Trune, J Beth Kempton
Mar 17, 2010·Biochemical and Biophysical Research Communications·Kyunghee X Kim, Daniel C Marcus
Sep 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Mohamed Hamid
Nov 26, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Fabrice PiuCarl LeBel
Nov 10, 2015·Nature Communications·Yves CazalsChristian Gestreau
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Dennis R Trune, Barbara Canlon
Sep 27, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Florian Lang, Ekaterina Shumilina
Sep 22, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Hidetaka KumagamiHaruo Takahashi
Jan 29, 2011·The Laryngoscope·Xiaobo WangFabrice Piu
Aug 4, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Paul R LambertCarl Lebel
Oct 26, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Arne LiebauStefan K Plontke
Sep 22, 2009·Expert Opinion on Therapeutic Targets·Florian LangVolker Vallon
Feb 19, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Carol MacArthurDennis R Trune
Jul 12, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Francis RoussetPascal Senn
Dec 11, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Michael H Froehlich, Paul R Lambert
Nov 8, 2020·International Journal of Pharmaceutics·Céline JaudoinAmélie Bochot
Sep 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery

❮ Previous
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