Regulation of endocytosis by the small GTP-ase Rab5.

Cytotechnology
M Zerial

Abstract

Rab5 is a small GTPase associated with the plasma membrane and the early endosomes. Expression of wild type rab5 and a mutant protein defective in GTP-binding in BHK cells led to alterations in the rate of endocytosis and in the morphology of endocytic organelles. The results obtained suggest that rab5 is a rate limiting GTPase that regulate the kinetics of both lateral fusion of early endosomes and fusion of plasma membrane-derived endocytic vesicles with early endosomes.

References

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Citations

Aug 20, 2003·Molecular Biology of the Cell·Victoria A Kelley, Jeffrey S Schorey
Aug 9, 2011·Experimental and Molecular Pathology·Christine A St PierreRobert W Finberg
Sep 13, 2005·Annals of the New York Academy of Sciences·Simon SedejRobert Zorec
Oct 18, 2011·Current Biology : CB·Chih-Chiang ChanP Robin Hiesinger
Jun 13, 2006·Biochimica Et Biophysica Acta·Paul A James, Kevin Talbot
May 26, 2004·Journal of Neuroscience Research·A G Rodriguez-GabinJ N Larocca

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