Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages

Endocrinology
S I SugaK Nakao

Abstract

We demonstrated endothelial production of C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, and its regulation by cytokines, including tumor necrosis factor-alpha (TNF alpha). We thus proposed that CNP can control vascular tone and growth as an endothelium-derived relaxing peptide. We also revealed the marked elevation of plasma CNP concentration in patients with septic shock, in which TNF alpha plays a significant part. As the interaction between endothelial cells (EC) and monocytes-macrophages plays a pivotal role in the pathogenesis of atherosclerosis, we investigated the effect of coculture of EC and macrophages on endothelial production of CNP. We used a human monocytic leukemia cell line, THP-1, which differentiates into macrophages when treated with phorbol 12-myristate 13-acetate. The coculture of EC and THP-1-derived macrophages enhanced CNP secretion by more than 10-fold compared with the single culture of EC or the coculture of EC and THP-1 without phorbol 12-myristate 13-acetate treatment. Prevention of direct contact between EC and THP-1-derived macrophages did not attenuate the increase in CNP secretion. Northern blotting revealed the augmentation of CNP messenger RNA expression...Continue Reading

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Citations

Aug 6, 2011·Peptides·Donald F SellittiMaria C Mendonça
Mar 25, 2019·The Journal of Clinical Hypertension·Steven G Chrysant
Jun 5, 2013·Pediatric Research·Timothy C R PrickettEric A Espiner
Jan 8, 2017·Clinical Chemistry·Timothy C R PrickettA Mark Richards
Oct 16, 2015·Journal of Receptor and Signal Transduction Research·Peng HuYuan Han Qin
Apr 1, 2016·Physiological Reviews·Michaela Kuhn
Sep 28, 1999·British Journal of Pharmacology·J M BrusqJ Kirilovsky
Jun 25, 2004·American Journal of Reproductive Immunology : AJRI·Krzysztof BryniarskiWłodzimierz Ptak
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T SaitoK Nakao
Jun 10, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Prasanna K SanthekadurArun J Sanyal

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