Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors

International Journal of Molecular Sciences
María Del Carmen GarcíaCarlos Diéguez

Abstract

Obesity rates and the burden of metabolic associated diseases are escalating worldwide Energy burning brown and inducible beige adipocytes in human adipose tissues (ATs) have attracted considerable attention due to their therapeutic potential to counteract the deleterious metabolic effects of nutritional overload and overweight. Recent research has highlighted the relevance of resident and recruited ATs immune cell populations and their signalling mediators, cytokines, as modulators of the thermogenic activity of brown and beige ATs. In this review, we first provide an overview of the developmental, cellular and functional heterogeneity of the AT organ, as well as reported molecular switches of its heat-producing machinery. We also discuss the key contribution of various interleukins signalling pathways to energy and metabolic homeostasis and their roles in the biogenesis and function of brown and beige adipocytes. Besides local actions, attention is also drawn to their influence in the central nervous system (CNS) networks governing energy expenditure.

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Citations

Aug 2, 2019·Hormone Molecular Biology and Clinical Investigation·Hamid Alizadeh, Alireza Safarzade
Jun 14, 2019·Obesity Surgery·Gian Franco AdamiRenzo Cordera
Apr 9, 2020·Frontiers in Endocrinology·Farah Omran, Mark Christian
Jul 28, 2019·Nutrients·Laura Di RenzoAntonino De Lorenzo
Dec 15, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Manuel Sanchez-AlavezMaria Cecilia Garibaldi Marcondes

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Methods Mentioned

BETA
flow cytometry
transgenic
gene-knockout
antisense oligonucleotide

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