Regulation of energy expenditure by estradiol in premenopausal women

Journal of Applied Physiology
Edward L MelansonWendy M Kohrt

Abstract

Suppressing sex hormones in women for 1 wk reduces resting energy expenditure (REE). The effects of more chronic suppression on REE and other components of total energy expenditure (TEE), and whether the reduction in REE is specifically due to loss of estradiol (E2), are not known. We compared the effects of 5 mo of sex hormone suppression (gonadotropin releasing hormone agonist therapy, GnRHAG) with placebo (PL) or E2 add-back therapy on REE and the components of TEE. Premenopausal women received GnRHAG (leuprolide acetate 3.75 mg/mo) and were randomized to receive transdermal therapy that was either E2 (0.075 mg/d; n = 24; means ± SD, aged = 37 ± 8 yr, BMI = 27.3 ± 6.2 kg/m(2)) or placebo (n = 21; aged = 34 ± 9 yr, BMI = 26.8 ± 6.2 kg/m(2)). REE was measured by using a metabolic cart, and TEE, sleep EE (SEE), exercise EE (ExEE, 2 × 30 min bench stepping), non-Ex EE (NExEE), and the thermic effect of feeding (TEF) were measured by using whole room indirect calorimetry. REE decreased in GnRHAG+PL [mean (95% CI), -54 (-98, -15) kcal/d], but not GnRHAG+E2 [+6 (-33, +45) kcal/d] (difference in between-group changes, P < 0.05). TEE decreased in GnRHAG+PL [-128 (-214, -41) kcal/d] and GnRHAG+E2 [-96 (-159, -32) kcal/d], with no sign...Continue Reading

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Citations

Mar 7, 2018·Medicine and Science in Sports and Exercise·Edward L MelansonWendy M Kohrt
Apr 11, 2018·American Journal of Physiology. Endocrinology and Metabolism·Kathleen M GavinWendy M Kohrt
Jul 13, 2018·Exercise and Sport Sciences Reviews·Kathleen M GavinEdward L Melanson
Jul 6, 2019·Medicine and Science in Sports and Exercise·Vanessa D SherkPaul S Maclean
Feb 28, 2017·JCI Insight·Altan ErcanPeter A Nigrovic
Feb 6, 2020·Journal of Cachexia, Sarcopenia and Muscle·Sarianna SipiläEija K Laakkonen
Dec 10, 2016·Frontiers in Nutrition·Erin D GilesPaul S MacLean
Mar 8, 2019·JCI Insight·Gail A GreendaleArun S Karlamangla
Mar 24, 2017·Human Reproduction Update·Brigitte LeenersLori Asarian
Dec 5, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L Isacco, J L Miles-Chan
Apr 24, 2018·BioResearch Open Access·Kelly A BosakLaura E Martin
Jul 21, 2017·The New England Journal of Medicine·Wendy M Kohrt, Margaret E Wierman
Apr 17, 2020·Journal of Applied Physiology·Young-Min ParkKerrie L Moreau
Oct 31, 2020·Temperature : Multidisciplinary Biomedical Journal·Fiona C BakerAndrea Fuller
Dec 12, 2020·Environmental Research·Diana K HaggertyRita S Strakovsky

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