Regulation of energy metabolism in the growth plate and osteoarthritic chondrocytes

Rheumatology International
Elena V Tchetina, Galina A Markova

Abstract

Osteoarthritis (OA) is a chronic disorder associated mainly with pain, limited range of motion, stiffness, low-grade systemic inflammation, and articular cartilage destruction. Recent studies have demonstrated the involvement of chondrocyte differentiation (hypertrophy) as one of the mechanisms in cartilage degradation in OA. This implicates the involvement of principal changes in the regulation of cellular function associated with profound alterations in chondrocyte energy metabolism in the course of cartilage resorption. Therefore, this review describes the major energy-generating pathways and their regulatory molecules used by the growth plate chondrocytes during endochondral ossification and by articular chondrocytes in OA. These regulatory molecules facilitate either the glycolytic pathway of energy generation, which controls cell proliferation, or mitochondrial oxidative phosphorylation promoted by AMPK and sirtuins and responsible for tissue regeneration. Consideration of the disturbances in energy metabolic pathways associated with OA might provide an approach to disclose the primary causes of the disease's development and progression. Medline/PubMed was searched for publications in English using key words: osteoarthrit...Continue Reading

References

Oct 15, 1991·Biochemical and Biophysical Research Communications·P PolleselloB J Kvam
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J L StamboughB T Storey
Aug 1, 1996·Journal of Cellular Physiology·R RajpurohitI M Shapiro
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·H ShimC V Dang
Dec 2, 1999·Experimental Cell Research·B Vanhaesebroeck, M D Waterfield
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E TchetinaA R Poole
Sep 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sara TavellaSilvio Garofalo
Dec 22, 2004·International Orthopaedics·David PfanderBernd Swoboda
Jun 7, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rieko YagiWalter E Horton
Apr 26, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alice Fiona Ford-HutchinsonFrank Robert Jirik
Feb 12, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chanika PhornphutkulPhilip A Gruppuso
Feb 19, 2008·The Journal of Biological Chemistry·Huafeng ZhangGregg L Semenza
Apr 29, 2008·Molecular Cell·Dana M GwinnReuben J Shaw
Nov 22, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Odile GabayChristelle Sanchez
Nov 26, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Pascale Pottie GegoutNathalie Presle
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Oct 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jolene BohenskyIrving M Shapiro
Mar 10, 2010·Journal of Internal Medicine·R H StraubG Pongratz
May 7, 2010·Bone·Elisa Araldi, Ernestina Schipani
May 21, 2010·Current Opinion in Rheumatology·MaryFran R Sowers, Carrie A Karvonen-Gutierrez
Jun 1, 2010·Annals of the Rheumatic Diseases·Jenny L ScottDavid A Young
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini
Jan 5, 2011·Nature Reviews. Rheumatology·Francisco J BlancoCristina Ruiz-Romero
Mar 2, 2011·Current Osteoporosis Reports·Erinn B RankinErnestina Schipani
Apr 1, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Feng Wang, Yue Zhu

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Citations

Jun 17, 2020·Journal of Biomechanical Engineering·Shannon K WalshCorinne R Henak
May 30, 2020·Cellular and Molecular Life Sciences : CMLS·Yuzhe HeLidong Wu
Apr 10, 2019·International Journal of Molecular Sciences·Holger JahrThomas Pufe
Jul 16, 2019·Journal of Molecular Histology·Hui-Qing LongBing Li
Mar 9, 2021·Drug Discovery Today·Xin LiLing Ye
May 30, 2020·Developmental Cell·Steve StegenGeert Carmeliet
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Pranidhi BaddamDaniel Graf
Nov 19, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shannon K WalshCorinne R Henak

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