Regulation of epithelial transport in the jejunal mucosa of the guinea pig by neurokinins.

Life Sciences
R Mathison, J S Davison

Abstract

This study characterizes the actions of the neurokinins and calcitonin-gene related peptide (CGRP) on electrolyte transport across the mucosa of the guinea pig jejunum in vitro in a modified Ussing chamber. By following changes in short circuit current (Isc) induced by substance P (SP) and neurokinins A & B (NKA & NKB) in the presence and absence of tetrodotoxin (TTX) and atropine, it was established that two distinct neurokinin receptors are involved in the regulation of electrolyte transport. NKA preferentially activates a neuronal receptor since the actions of this neurokinin were inhibited by both TTX and atropine. SP, whose actions were reduced to a lesser extent by TTX and atropine, is considered to activate preferentially a receptor on the epithelial cells. The third neurokinin, NKB, appears to act non-selectively on both the neuronal and epithelial receptors. CGRP, which per se did not affect Isc, markedly potentiated the increases in Isc induced by SP and NKB, and thus acts synergistically with the epithelial neurokinin receptor. These results suggest that two distinct neurokinin receptors (the NK-1 and the NK-2) regulate epithelial transport in the jejunal mucosa of the guinea pig, and furthermore indicate that at lea...Continue Reading

Citations

Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Oct 1, 2003·Clinical and Experimental Pharmacology & Physiology·Ian M Coupar, Juliana L Di Iulio
Feb 1, 1993·Journal of Autonomic Pharmacology·C A MaggiA Giachetti
Dec 31, 1997·The American Journal of Physiology·W MacNaughtonS Vanner
Jun 4, 1999·Journal of Gastroenterology and Hepatology·C MakridisL Knutson

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