Regulation of ER-Golgi Transport Dynamics by GTPases in Budding Yeast

Frontiers in Cell and Developmental Biology
Yasuyuki SudaAkihiko Nakano

Abstract

A large number of proteins are synthesizedde novoin the endoplasmic reticulum (ER). They are transported through the Golgi apparatus and then delivered to their proper destinations. The ER and the Golgi play a central role in protein processing and sorting and show dynamic features in their forms. Ras super family small GTPases mediate the protein transport through and between these organelles. The ER-localized GTPase, Sar1, facilitates the formation of COPII transport carriers at the ER exit sites (ERES) on the ER for the transport of cargo proteins from the ER to the Golgi. The Golgi-localized GTPase, Arf1, controls intra-Golgi, and Golgi-to-ER transport of cargo proteins by the formation of COPI carriers. Rab GTPases localized at the Golgi, which are responsible for fusion of membranes, are thought to establish the identities of compartments. Recent evidence suggests that these small GTPases regulate not only discrete sites for generation/fusion of transport carriers, but also membrane dynamics of the organelles where they locate to ensure the integrity of transport. Here we summarize the current understandings about the membrane traffic between these organelles and highlight the cutting-edge advances from super-resolution l...Continue Reading

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Citations

Jul 11, 2019·Journal of Cell Science·Takuro TojimaAkihiko Nakano
Aug 7, 2018·Cell Biology International·Pelin MakaraciKyoungtae Kim
Sep 3, 2018·Histochemistry and Cell Biology·Jaakko Saraste, Michaël Marie
Nov 17, 2020·Frontiers in Cellular Neuroscience·Chang Geon ChungSung Bae Lee
Jan 7, 2021·International Journal of Molecular Sciences·Susana Sabido-BozoManuel Muñiz
Mar 7, 2020·Current Opinion in Cell Biology·Laura L Thomas, J Christopher Fromme

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Methods Mentioned

BETA
GTPases
GTPase
nucleotide exchange
glycosylation

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