Regulation of ER-mitochondria contacts by Parkin via Mfn2

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Valentina BassoElena Ziviani

Abstract

Parkin, an E3 ubiquitin ligase and a Parkinson's disease (PD) related gene, translocates to impaired mitochondria and drives their elimination via autophagy, a process known as mitophagy. Mitochondrial pro-fusion protein Mitofusins (Mfn1 and Mfn2) were found to be a target for Parkin mediated ubiquitination. Mfns are transmembrane GTPase embedded in the outer membrane of mitochondria, which are required on adjacent mitochondria to mediate fusion. In mammals, Mfn2 also forms complexes that are capable of tethering mitochondria to endoplasmic reticulum (ER), a structural feature essential for mitochondrial energy metabolism, calcium (Ca2+) transfer between the organelles and Ca2+ dependent cell death. Despite its fundamental physiological role, the molecular mechanisms that control ER-mitochondria cross talk are obscure. Ubiquitination has recently emerged as a powerful tool to modulate protein function, via regulation of protein subcellular localization and protein ability to interact with other proteins. Ubiquitination is also a reversible mechanism, which can be actively controlled by opposing ubiquitination-deubiquitination events. In this work we found that in Parkin deficient cells and parkin mutant human fibroblasts, the t...Continue Reading

Citations

May 28, 2019·Cells·Monica Vara-PerezPatrizia Agostinis
Nov 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yi LiuXiongwei Zhu
Nov 30, 2019·Frontiers in Neuroscience·Sandeep Kumar BarodiaVictor Tapias
Jul 7, 2020·Frontiers in Cell and Developmental Biology·Lingna XuChao Tong
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Shubhangini Tiwari, Sarika Singh
Aug 9, 2020·Frontiers in Cell and Developmental Biology·Ming YangLin Sun
Feb 14, 2019·International Journal of Molecular Sciences·Gaia FaveroRita Rezzani
Jun 4, 2019·Frontiers in Physiology·Mafalda Escobar-Henriques, Mariana Joaquim
Jun 30, 2019·Cellular and Molecular Life Sciences : CMLS·Andrew N Bayne, Jean-François Trempe
Feb 6, 2020·Frontiers in Cell and Developmental Biology·Philippe Delmotte, Gary C Sieck
Jan 1, 2020·Journal of Clinical Medicine·Clara Berenguer-EscuderRejko Krüger
Sep 10, 2020·Frontiers in Physiology·Zhenying ZuoHua-Feng Liu
Dec 25, 2019·Oxidative Medicine and Cellular Longevity·Gaia FaustiniArianna Bellucci
Mar 11, 2020·International Journal of Molecular Sciences·Lucia BarazzuolTito Calì
Feb 7, 2020·Cells·Ying WangZheng Dong
Jul 11, 2020·Cells·Ana Paula Magalhães RebeloMarta Giacomello
Oct 13, 2020·Frontiers in Neurology·Dajana GrossmannRejko Krüger
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Mariana Joaquim, Mafalda Escobar-Henriques
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Hyunsu JungSeok-Kyu Kwon
Jan 6, 2021·International Journal of Molecular Sciences·Debanjali DasguptaGary C Sieck
Jan 21, 2021·Translational Neurodegeneration·Iryna KamienievaJoanna Szczepanowska
Jan 21, 2021·Frontiers in Cell and Developmental Biology·Jannik PrasuhnKishore R Kumar
Feb 6, 2020·Mechanisms of Ageing and Development·Yasmine J LiuRiekelt H Houtkooper
May 26, 2020·Neuroscience Research·Yoshikuni Mizuno
Feb 2, 2021·Frontiers in Neuroscience·Helen ZhaoGabriel G Haddad
Nov 17, 2020·Cellular and Molecular Neurobiology·Reza Raeisossadati, Merari F R Ferrari
Dec 19, 2020·Cell Death and Differentiation·Emma Louise Wilson, Emmanouil Metzakopian
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Tsu-Kung LinTzu-Jou Wang
Mar 5, 2021·Developmental Cell·Matthew Yoke Wui NgAnne Simonsen
Feb 19, 2021·Frontiers in Cell and Developmental Biology·Cara R SchiavonUri Manor
Mar 7, 2021·Biomedicines·Nuno Santos Leal, Luís Miguel Martins
Jun 23, 2019·Mitochondrion·B N WhitleyS Hoppins
Aug 31, 2020·Biochimica Et Biophysica Acta. Bioenergetics·Cynthia AlsayyahMickael M Cohen
Apr 3, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Luana NaiaA Cristina Rego
Apr 17, 2021·Genes & Development·Maja PetkovicYuh Nung Jan
May 20, 2021·Mitochondrion·S S MichurinaYe V Parfyonova

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