Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase

Neuroscience
H FleisigS R Vincent

Abstract

Signaling by a variety of ligands including epidermal growth factor, betacellulin and neuregulin is mediated by the ErbB family of receptor tyrosine kinases. Studies on the prostate have shown that ErbB2 phosphorylation and signaling can be regulated by prostatic acid phosphatase, a histidine acid phosphatase which can dephosphorylate phospho-tyrosine residues in the ErbB2 receptor. Here we report that the histidine acid phosphatase ACPT (testicular acid phosphatase), which is highly homologous to the prostatic acid phosphatase, can dephosphorylate the ErbB4 receptor, which is known to play important roles in neuronal differentiation and synaptogenesis. ACPT and ErbB4 are both expressed in the brain where they are enriched at post-synaptic sites, and furthermore they can be co-immunoprecipitated from brain. We demonstrate that ACPT can inhibit basal and neuregulin-induced tyrosine phosphorylation of ErbB4. We also show that ACPT-dependent dephosphorylation can regulate the proteolytic cleavage of ErbB4, and this process can be reversed by applying the tyrosine phosphatase inhibitor, pervanadate. Furthermore, neuregulin-dependent differentiation of PC12 cells expressing ErbB4 is prevented by co-expressing ACPT. These results ind...Continue Reading

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Citations

Dec 18, 2013·BMC Microbiology·Olabisi Oluwabukola CokerPrasit Palittapongarnpim
Nov 3, 2012·PloS One·Laura W HarrisSabine Bahn
Apr 11, 2006·Harvard Review of Psychiatry·Edward M ScolnickPamela Sklar
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Nov 9, 2015·Cell and Tissue Research·Hwajung ChoiEui-Sic Cho
Jun 22, 2015·Molecular Neurobiology·Ying-mei LuXiao-ming Li
May 18, 2017·European Journal of Human Genetics : EJHG·Claire El SmithAlan J Mighell
Dec 13, 2005·The Journal of Biological Chemistry·Marie-France LiséAlaa El-Husseini
Dec 21, 2007·The Biochemical Journal·Daniel J Rigden
Jul 12, 2017·Frontiers in Physiology·Claire E L SmithAlan J Mighell
Apr 27, 2021·Frontiers in Aging Neuroscience·Guan-Yong OuWei-Jiang Zhao

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