PMID: 7088453Jul 1, 1982Paper

Regulation of erythropoiesis in fetus and mother during normal pregnancy

Obstetrics and Gynecology
J ZivnýV Andrasová


The activity of the hormone erythropoietin was assayed (1) in the amniotic fluid of healthy women in the tenth to 16th weeks of pregnancy who had artificial interruption of pregnancy and (2) in the urinary output of healthy pregnant and nonpregnant women. Erythropoietin activity in concentrated urine increased significantly between the 24th and 31st weeks of pregnancy. No erythropoietin activity was demonstrated in amniotic fluid at the tenth week of pregnancy, even when the fluid was concentrated, but it was demonstrated in concentrated amniotic fluid from the 11th to 16th weeks. The assay results prove, indirectly, the hypothesis that increased production of erythrocytes in pregnancy is mediated by the erythropoietin humoral mechanism in both fetus and mother. Erythropoiesis in the fetus probably is regulated by erythropoietin as early as the 11th week of pregnancy.

Related Concepts

Amniotic Fluid Index
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy Trimester, Third

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.