PMID: 9187056Jan 1, 1997Paper

Regulation of eukaryotic messenger RNA turnover

Progress in Nucleic Acid Research and Molecular Biology
L E Rajagopalan, J S Malter

Abstract

We have demonstrated the existence of multiple mRNA binding proteins that interact specifically with defined regions in posttranscriptionally regulated mRNAs. These domains appear to be destabilizers whose function can be attenuated by the interaction with the specific binding proteins. Thus, the ability to alter mRNA decay rates on demand, given different environmental or intracellular conditions, appears to be mediated by controlling the localization, activity, and overall function of the cognate binding protein. Based on our limited experience, we predict that most, if not all, of similarly regulated mRNAs will ultimately be found to interact with regulatory mRNA binding proteins. Under conditions whereby the mRNA binding proteins are constitutively active (e.g., tumor cell lines), abnormal mRNA decay will result, with accumulation and overtranslation. Such appears to be the case for cytokines and possibly amyloid protein precursor mRNAs in cancer and Alzheimer's disease, respectively. Conversely, mutagenesis of these critical 3' untranslated region elements will likely have comparable deleterious effects on the regulation of gene expression. To the extent that such derangements exist in human disease, attention to understan...Continue Reading

Citations

Jul 3, 1998·Nucleic Acids Research·L E RajagopalanJ S Malter
Mar 14, 2000·Molecular and Cellular Biology·K T Militello, L K Read
Jan 15, 2002·DNA and Cell Biology·J F LoringR Somogyi
Sep 8, 2001·American Journal of Physiology. Cell Physiology·A O GramoliniB J Jasmin
Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Joe V Chakkalakal, Bernard J Jasmin
Sep 21, 2004·American Journal of Medical Genetics. Part a·L A KatzJ C Murray
Jan 30, 2015·Molecular Neurobiology·Christian ClementWalter J Lukiw
Jan 7, 2004·Journal of the Society for Gynecologic Investigation·J J WangJ C Rose
Sep 11, 2004·The Journal of Biological Chemistry·David T FritzMelissa B Rogers
Feb 20, 1999·Infection and Immunity·B S ZwillingW Lafuse
Mar 17, 1999·Methods : a Companion to Methods in Enzymology·G M Wilson, G Brewer

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