Regulation of exercise blood flow: Role of free radicals

Free Radical Biology & Medicine
Joel D TrinityRussell S Richardson

Abstract

During exercise, oxygen and nutrient rich blood must be delivered to the active skeletal muscle, heart, skin, and brain through the complex and highly regulated integration of central and peripheral hemodynamic factors. Indeed, even minor alterations in blood flow to these organs have profound consequences on exercise capacity by modifying the development of fatigue. Therefore, the fine-tuning of blood flow is critical for optimal physical performance. At the level of the peripheral circulation, blood flow is regulated by a balance between the mechanisms responsible for vasodilation and vasoconstriction. Once thought of as toxic by-products of in vivo chemistry, free radicals are now recognized as important signaling molecules that exert potent vasoactive responses that are dependent upon the underlying balance between oxidation-reduction reactions or redox balance. Under normal healthy conditions with low levels of oxidative stress, free radicals promote vasodilation, which is attenuated with exogenous antioxidant administration. Conversely, with advancing age and disease where background oxidative stress is elevated, an exercise-induced increase in free radicals can further shift the redox balance to a pro-oxidant state, impa...Continue Reading

Associated Clinical Trials

References

Mar 1, 1992·Medicine and Science in Sports and Exercise·W L Kenney, J M Johnson
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·R AaslidH Nornes
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Feb 1, 1986·Circulation Research·M B HigginbothamF R Cobb
Sep 1, 1985·The Journal of Physiology·P Andersen, B Saltin
Aug 31, 1982·Biochemical and Biophysical Research Communications·K J DaviesL Packer
Sep 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M GlobusS Stern
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·M D Koskolou, D C McKenzie
Nov 1, 1993·International Journal of Sports Medicine·J A DuarteJ M Soares
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·J J MoraineR Naeije
Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
Apr 30, 1998·Current Opinion in Cell Biology·T Finkel
Jul 20, 1999·Experimental & Molecular Medicine·S G Rhee
Sep 1, 1999·European Journal of Biochemistry·R A SmithM P Murphy
Feb 11, 2000·Journal of Science and Medicine in Sport·E F Coyle
Mar 17, 2000·Circulation Research·K K GriendlingM Ushio-Fukai
Sep 8, 2000·Stroke; a Journal of Cerebral Circulation·Y Iida, Z S Katusic
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J A L CalbetB Saltin
Feb 8, 2003·Circulation Research·Hiroto MiuraDavid D Gutterman
Mar 11, 2003·Journal of Applied Physiology·Damian M BaileyRussell S Richardson
Jun 25, 2003·Toxicology·Maria L Urso, Priscilla M Clarkson
Sep 6, 2003·American Journal of Physiology. Heart and Circulatory Physiology·J Scott McNallyDavid G Harrison
Apr 1, 1954·The American Journal of Medicine·P SCHEINBERGM SASLAW
Oct 29, 2003·Hypertension·Yoshihiro Taniyama, Kathy K Griendling
Nov 25, 2003·Advances in Physiology Education·R S Richardson
Dec 12, 2003·Journal of Cardiovascular Pharmacology·Annemieke A de GrootStephan L M Peters
Mar 3, 2004·Free Radical Biology & Medicine·Mark T GladwinRakesh P Patel

❮ Previous
Next ❯

Citations

Jan 9, 2019·European Journal of Applied Physiology·Paul T MorganJoanna L Bowtell
Jan 24, 2019·Sports Medicine·Joanna Bowtell, Vincent Kelly
Mar 4, 2017·Journal of Applied Physiology·Daniel M HiraiJ Alberto Neder
Dec 31, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Jacqueline K LimbergJaume Padilla
Jun 29, 2018·Infectious Disorders Drug Targets·Hourieh Alkadi
Jan 7, 2019·Molecular Diversity·Fatih SonmezMustafa Kucukislamoglu
Sep 12, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Kevser TuralAyşen Aksoyek
May 17, 2019·Journal of Applied Physiology·Christopher J de Vries, Darren S DeLorey
Apr 2, 2020·Nature Reviews. Molecular Cell Biology·Helmut Sies, Dean P Jones
Aug 27, 2019·Frontiers in Immunology·Mark R ZielinskiNoel R Rose
Feb 20, 2020·Cellular and Molecular Life Sciences : CMLS·Ilaria BellezzaRosario Donato
Jan 1, 2021·Clinical, Cosmetic and Investigational Dermatology·Ia KhmaladzeAlain Mavon
Aug 18, 2020·Medicine and Science in Sports and Exercise·Trevor J KingJamie F Burr
Apr 4, 2021·Redox Biology·Mari Carmen Gomez-CabreraJose Viña
Oct 2, 2021·Critical Reviews in Food Science and Nutrition·Yinghui LiJunling Shi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Russell S RichardsonDamian M Bailey
Congestive Heart Failure
Rajesh Sharma, Madalyn N Davidoff
Annual Review of Medicine
H Drexler, A Coats
Journal of Anatomy
A McArdle, M J Jackson
© 2022 Meta ULC. All rights reserved