Regulation of experimental allergic encephalomyelitis. III. Demonstration of effector cells in tolerant rats

European Journal of Immunology
J H Holda, R H Swanborg

Abstract

Effector cells, which transfer experimental allergic encephalomyelitis (EAE), can be demonstrated in the spleens of Lewis rats which have been rendered tolerant to myelin basic protein (BP). Transfer of EAE was achieved following in vitro culture of tolerant donor spleen cells with antigen. The donor animals were, themselves, protected against EAE induced by active challenge with BP in complete Freund's adjuvant, although BP-activated effector spleen cells could partially override this protection. The finding that effector cells are present in unresponsive animals supports the hypothesis that immunologic self tolerance is actively regulated by suppressor mechanisms.

References

Sep 1, 1976·The Journal of Experimental Medicine·L Ortiz-Ortiz, W O Weigle
Aug 1, 1976·Journal of the National Cancer Institute·A J TrevesM Feldman
Oct 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·S LEVINE, E J WENK
Mar 31, 1965·Annals of the New York Academy of Sciences·E C ALVORDM W KIES

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Citations

Jan 1, 1988·Immunologic Research·C J Kelly, E G Neilson
May 1, 1989·Kidney International·E G Neilson
Dec 14, 2007·Journal of Neuroimmunology·Richard A O'Connor, Stephen M Anderton
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroshi T IchikawaBenjamin M Segal

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