Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1/IGF-binding protein-3 complex (IGF-1/IGFBP3)

The Journal of Clinical Investigation
A E Lovett-RackeM K Racke

Abstract

Insulin-like growth factor (IGF)-1 is a cytokine that promotes oligodendrocyte development and myelin production. This study investigated whether treatment of chronic, relapsing murine experimental autoimmune encephalomyelitis (EAE) with IGF-1 or IGF-1 associated with its binding protein, IGFBP3, altered the course of disease. Administration of IGF-1/IGFBP3 (1-100 mg/kg per day) delayed the onset of disease in a dose-dependent manner and histologic examination showed a delay in inflammatory cells entering the central nervous system. However, once signs of EAE developed, disease was enhanced in the mice that had been given the highest dose of IGF-1/IGFBP3. Treatment with IGF-1/IGFBP3 after the onset of signs resulted in a severe relapse. Administration of free IGF-1 (10 mg/kg per day) provided mild protection when given before disease onset, but did not significantly alter the course of disease if given after disease onset. Possible mechanisms that could explain the altered disease in IGF-1/IGFBP3-treated mice included (a) IGF-1/IGFBP3 administration delayed the onset of EAE by downregulating ICAM-1 gene expression in the central nervous system, and (b) IGF-1/IGFBP3 treatment of EAE resulted in more severe disease due to enhance...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S KomolyC A Bondy
Jan 1, 1992·Annual Review of Immunology·R MartinD E McFarlin
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F A McMorrisR W Furlanetto
Nov 1, 1994·Endocrinology·R R Reinhardt, C A Bondy
Nov 1, 1994·The Journal of Experimental Medicine·M K RackeM Röcken
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L YaoH D Webster
Jan 1, 1993·The Journal of Experimental Medicine·J L BaronC A Janeway
Jan 1, 1994·Annals of Internal Medicine·J W Kolaczynski, J F Caro
Nov 1, 1993·Experimental Neurology·M E LewisJ L Vaught
Aug 1, 1993·The Journal of Clinical Investigation·R ClarkP Jardieu
Jan 1, 1993·Annual Review of Physiology·W S Cohick, D R Clemmons
Jan 1, 1995·Progress in Growth Factor Research·S AdamsA Sommer

❮ Previous
Next ❯

Citations

Oct 29, 2002·Trends in Immunology·Richard M RansohoffMoses Rodriguez
Jul 27, 1999·Neuropathology and Applied Neurobiology·D GvericJ Newcombe
May 17, 2000·The Journal of Experimental Medicine·R M Ransohoff, C Trebst
May 19, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R LanzilloV B Morra
May 12, 2005·Hormone Research·Robert J FerryLorraine E Levitt Katz
Dec 15, 2010·Drugs·Aaron BosterMichael K Racke
Jun 17, 2008·Current Opinion in Neurology·Michael K Racke
Apr 23, 2004·Expert Opinion on Investigational Drugs·Martin Stangel
Feb 26, 2003·Annals of Neurology·Martin KerschensteinerReinhard Hohlfeld
Jan 27, 2004·Journal of Neuroscience Research·Hans-Gert BernsteinUwe Lendeckel
Nov 8, 2008·Annals of the New York Academy of Sciences·Tamir Ben-Hur, Steven A Goldman
Jul 13, 2007·Glia·Anna WilliamsCatherine Lubetzki
Jun 28, 2011·Medical Hypotheses·Rami Bou Khalil
Jun 7, 2014·Frontiers in Molecular Neuroscience·Thomas Blank, Marco Prinz
May 29, 2007·International Review of Neurobiology·Daniel ChesikJacques De Keyser
Aug 22, 2016·Journal of Neuroimmunology·Amy E Lovett-Racke
Jun 16, 2017·The Journal of Comparative Neurology·Azita Parvaneh TafreshiFarshid Noorbakhsh
May 8, 2004·Brain : a Journal of Neurology·Jagat R KanwarGeoffrey W Krissansen
Oct 17, 2018·Glia·Christos P PapaneophytouKleopas A Kleopa
Apr 9, 2002·Multiple Sclerosis : Clinical and Laboratory Research·J A FrankT Leist
Oct 24, 2014·EMBO Molecular Medicine·Daniel BilbaoNadia Rosenthal
Jul 28, 2004·Journal of Leukocyte Biology·Ron Kooijman, Astrid Coppens
Sep 1, 2005·Endocrine Reviews·V C RussoG A Werther
Sep 15, 2018·Frontiers in Endocrinology·Huihua Ding, Tianfu Wu
Feb 17, 2001·European Journal of Immunology·L R ArredondoM K Racke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.