Regulation of expression of atypical orphan response regulators of Helicobacter pylori

Microbiological Research
Stefanie MüllerDagmar Beier

Abstract

The human gastric pathogen Helicobacter pylori exhibits a remarkably small repertoire of transcriptional regulators including three complete two-component systems as well as the orphan response regulators HP1021 and HP1043. Both HP1021 and HP1043 show atypical receiver sequences and are required for the normal cell growth of H. pylori. Recently, we demonstrated that phosphorylation of HP1021 and HP1043 according to the two-component paradigm is not a prerequisite for the cell growth-associated functions of these response regulators, raising the question of how the activity of this regulatory proteins is modulated. Here, we report that strict transcriptional control of its expression is not involved in the cell-growth associated function of HP1021. We show that expression of hp1043 is controlled both on the post-transcriptional or post-translational level and by transcriptional regulation. Furthermore, we provide evidence that hp1043 can be replaced by the orthologous gene cj0355 from Campylobacter jejuni.

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Citations

Feb 24, 2011·Functional & Integrative Genomics·Martin Stahl, Alain Stintzi
Oct 12, 2013·Journal of Microbiological Methods·Mark S McClainTimothy L Cover
Apr 10, 2007·International Journal of Medical Microbiology : IJMM·Christine JosenhansSebastian Suerbaum
Jun 18, 2015·Molecular Microbiology·Chiu-Lien HungWen-Ching Wang
Jul 29, 2016·Frontiers in Microbiology·Tara Grinnage-PulleyQijing Zhang
May 19, 2019·Annual Review of Microbiology·Rong GaoAnn M Stock
Dec 19, 2019·Pharmaceutics·Andrés GonzálezÁngel Lanas
Jul 28, 2018·Frontiers in Microbiology·Pawel JaworskiAnna Zawilak-Pawlik
Jun 3, 2017·Frontiers in Microbiology·Hana TuronovaOdile Tresse
Aug 8, 2021·International Journal of Molecular Sciences·Annamaria ZannoniVincenzo Scarlato

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