Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors

Anatomy and Embryology
Yoshihiko SatohGen Yamada

Abstract

Members of the fibroblast growth factor (FGF) family play diverse roles during the development and patterning of various organs. In human and mice, 22 FGFs and four receptors derived from several splice variants are present. Redundant expression and function of FGF genes in organogenesis have been reported, but their roles in embryonic external genitalia, genital tubercle (GT), development have not been studied in detail. To address the role of FGF during external genitalia development, we have analyzed the expression of FGF genes (Fgf8, 9, 10) and receptor genes (Fgfr1, r2IIIb, r2IIIc) in GT of mice. Furthermore, Fgf10 and Fgfr2IIIb mutant mice were analyzed to elucidate their roles in embryonic external genitalia development. Fgfr2IIIb was expressed in urethral plate epithelium during GT development. Fgfr2IIIb mutant mice display urethral dysmorphogenesis. Marker gene analysis for urethral plate and bilateral mesenchymal formation suggests the existence of epithelial-mesenchymal interaction during urethral morphogenesis. Therefore, FGF10/FGFR2IIIb signals seem to constitute a developmental cascade for such morphogenesis.

Citations

Jul 14, 2012·Differentiation; Research in Biological Diversity·Sarah D BlaschkoLaurence S Baskin
Mar 23, 2011·The Journal of Urology·Ashley E RossEdward M Schaeffer
Dec 10, 2009·Journal of Pediatric Urology·Yoshiyuki KojimaYutaro Hayashi
Apr 25, 2006·Clinical Genetics·J M MilunskyD B Everman
May 31, 2014·Biochimica Et Biophysica Acta·Aki MurashimaGen Yamada
Mar 31, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Masayo HaradaGen Yamada
May 18, 2016·Reproductive Toxicology·Maxwell C K LeungThomas B Knudsen
Apr 7, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G YamadaY Chen
Sep 20, 2007·European Journal of Human Genetics : EJHG·Kentaro SuzukiGen Yamada
Dec 19, 2007·Asian Journal of Andrology·Donghua XieCraig F Donatucci
Sep 25, 2017·Endocrinology·Stefan Bagheri-FamVincent R Harley
Dec 20, 2012·Nature Communications·Masayoshi TokitaKazuo Suzuki
Apr 20, 2018·Nature Reviews. Urology·Shoko MatsushitaGen Yamada
Oct 8, 2019·Differentiation; Research in Biological Diversity·Taiju HyugaGen Yamada
Jun 18, 2015·Development·Marissa L GredlerMartin J Cohn
Oct 27, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gerard A TarulliMarilyn B Renfree

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.