PMID: 6976979Feb 1, 1982Paper

Regulation of extraadrenal steroid 21-hydroxylase activity. Increased conversion of plasma progesterone to deoxycorticosterone during estrogen treatment of women pregnant with a dead fetus

The Journal of Clinical Investigation
P C MacDonaldC R Parker

Abstract

We measured deoxycorticosterone (DOC) and progesterone (P) in plasma of 47 women pregnant with a dead fetus and sequentially throughout gestation in 35 women pregnant with a live fetus. When P levels in plasma were low, the plasma levels of DOC in women pregnant with a dead fetus varied but usually were similar to those in women pregnant with a live fetus. However, when P levels were high, the levels of DOC in some women pregnant with a dead fetus were considerably lower than those in women pregnant with a live fetus. To test whether this finding was due to loss of transfer of DOC from fetus to mother or else loss of extraadrenal steroid 21-hydroxylase activity in the mother after death of the fetus, we conducted several studies. The levels of P and DOC in plasma of one woman remained constant from 30 min after fetal death until delivery occurred 13 h later. Estrogen treatment of four women pregnant with a dead fetus brought about an increase in plasma levels of DOC in three of the women. In one woman the ratio of plasma DOC to P was 0.015, a value similar to that found before fetal death, but was 0.003 after fetal death but before estrogen treatment. In two women pregnant with a dead fetus the transfer constants of conversion ...Continue Reading

References

Jul 8, 1975·Biochemical and Biophysical Research Communications·M S Soloff
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Citations

Aug 1, 1983·Journal of Steroid Biochemistry·A GueramiP C MacDonald
Oct 1, 1983·Journal of Steroid Biochemistry·M L Casey, P C MacDonald
Jul 1, 1988·Journal of Steroid Biochemistry·K NahoulR Scholler
Dec 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M NamikiT Sonoda
Aug 1, 1989·Baillière's Clinical Endocrinology and Metabolism·J M Davison, M D Lindheimer
Sep 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·D RogoffA Slominski
Mar 5, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marshall D Lindheimer, Phyllis August
Aug 1, 1982·The Journal of Clinical Investigation·M L Casey, P C MacDonald
Apr 12, 2014·American Journal of Primatology·Kimberley A PhillipsMary Lou Voytko
Jul 1, 1987·The Journal of Pediatrics·W L Miller, L S Levine
Jul 1, 1986·The Journal of Urology·D B KarpfG D Braunstein

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