PMID: 18203911Jan 22, 2008Paper

Regulation of fat synthesis by conjugated linoleic acid: lactation and the ruminant model

The Journal of Nutrition
D E BaumanL H Baumgard

Abstract

Conjugated linoleic acid (CLA) isomers effect an impressive range of biological processes including the ability to inhibit milk fatty acid synthesis. Although this has been demonstrated in several mammals, research has been most extensive with dairy cows. The first isomer shown to affect milk fat synthesis during lactation was trans-10, cis-12 CLA, and its effects have been well characterized including dose-response relationships. Recent studies have tentatively identified 2 additional CLA isomers that regulate milk fat synthesis. Regulation by CLA occurs naturally in dairy cows when specific CLA isomers produced as intermediates in rumen biohydrogenation act to inhibit milk fat synthesis; this physiological example of nutritional genomics is referred to as diet-induced milk fat depression. Molecular mechanisms for the reduction in mammary lipid synthesis involve a coordinated down-regulation of mRNA expression for key lipogenic enzymes associated with the complementary pathways of milk fat synthesis. Results provide strong evidence of a role for sterol response element-binding protein 1 and Spot 14 in this translational regulation. Effects of CLA on body fat accretion have also been investigated in nonlactating animals, but CL...Continue Reading

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Citations

Mar 25, 2009·Journal of Dairy Science·W M StoopJ A M van Arendonk
Feb 16, 2010·Journal of Animal Science·A J Lengi, B A Corl
Jul 1, 2010·Animal : an International Journal of Animal Bioscience·K J ShingfieldY Chilliard
Oct 30, 2013·Molecular Reproduction and Development·Baoyu JiaShien Zhu
Oct 28, 2015·Journal of Dairy Science·R BodkowskiA Wiliczkiewicz
Feb 24, 2009·Journal of Dairy Science·G ShwartzL H Baumgard
Sep 17, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M R FooteY R Boisclair
Mar 14, 2013·The Journal of Dairy Research·Eleni Tsiplakou, George Zervas
Jun 19, 2012·Molecular Nutrition & Food Research·Isabel Rubio-Aliaga

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