Regulation of fatty acid oxidation in untrained vs. trained men during exercise

The American Journal of Physiology
L S SidossisA R Coggan

Abstract

We have recently shown that increased carbohydrate flux decreases fat oxidation during exercise by inhibition of fatty acid entry into the mitochondria. Because endurance training reduces the rate of carbohydrate flux during exercise, we hypothesized that training increases fat oxidation by relieving this inhibition. To test this hypothesis, five sedentary and five endurance-trained men exercised on a cycle ergometer at an oxygen consumption (VO2) of approximately 2.0 l/min, representing 80 and 40% peak VO2, respectively. [1-13C]oleate and [1-14C]octanoate, long- and medium-chain fatty acids, respectively, were infused for the duration of the studies. Carbohydrate oxidation was significantly higher in the sedentary group (196 +/- 9 vs. 102 +/- 17 mumol.kg-1.min-1, P < 0.05). Oleate oxidation was higher in the trained group (3.8 +/- 0.6 vs. 1.9 +/- 0.3 mumol.kg-1.min-1, P < 0.05), whereas octanoate oxidation was not different between the two groups. The percentage of oleate that was taken up by tissues and oxidized was higher in the trained group (76 +/- 7 vs. 58 +/- 3%, P < 0.05). However, the percentage of octanoate taken up and oxidized was not different (82 +/- 3 vs. 85 +/- 4%, not significant). Because octanoate, unlike ole...Continue Reading

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Citations

Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Michelle Z Tucker, Lorraine P Turcotte
Aug 24, 2006·American Journal of Physiology. Endocrinology and Metabolism·K SahlinP K Pedersen
Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·B MorioP Ritz
Jul 29, 2003·Journal of Applied Physiology·Marlei E WaltonRonald G Haller
May 13, 2010·Scandinavian Journal of Medicine & Science in Sports·T IchinoseK Imaizumi
Jun 5, 2014·American Journal of Physiology. Endocrinology and Metabolism·Birgitte NellemannSøren Nielsen
Sep 11, 2004·Journal of Applied Physiology·Luc J C van Loon
Sep 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Carsten RoepstorffBente Kiens
May 14, 2009·Journal of Nutritional Science and Vitaminology·Naohisa NosakaMotoko Taguchi
Jul 22, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dominik PestaErich Gnaiger
Apr 1, 2019·Scandinavian Journal of Medicine & Science in Sports·Francisco J Amaro-GaheteJonatan R Ruiz
Jul 10, 2002·Obesity Research·Bret H GoodpasterDavid E Kelley
Feb 10, 2006·Journal of Applied Physiology·Tracy J HortonKristen Bourret
Aug 31, 2004·Journal of Applied Physiology·Michelle C VenablesAsker E Jeukendrup
Feb 14, 2002·Journal of Applied Physiology·Dorien P C van Aggel-LeijssenMarleen A van Baak

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