PMID: 6965303Jan 1, 1980Paper

Regulation of Fc fragment-induced murine spleen cell proliferation

The Journal of Experimental Medicine
E L Morgan, W O Weigle

Abstract

Murine splenic lymphocytes proliferate in response to supernatant material derived from Fc fragment-pulsed splenic adherent cells. The stimulatory supernatant results from the interaction of Fc fragments with adherent cells or adherent cell supernate. Isolation of the stimulatory material in the supernate by Sephadex chromatography revealed that the mitogenic component was a cleavage product of Fc with a mol wt of approximately 14,000. The spleen cell type responsible for the generation of mitogenic Fc subfragments appears to be a macrophage. Unstimulated macrophages release an active supernate without being exposed to Fc fragments. The supernate of unstimulated macrophages apparently contain an enzyme which is capable of cleaving Fc fragments into the 14,000-mol wt mitogenic molecules. The spleen cell population induced to proliferate in response to the adherent cell supernate is present in T-cell depleted and Sephadex G-10 filtered cell preparations. Depletion of cells bearing immunoglobulin on their surfaces results in a reduced proliferative response to the mitogenic supernatant material indicating that it is probably a B cell.

References

Jul 1, 1977·The Journal of Experimental Medicine·M A Berman, W O Weigle
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E TzehovalM Feldman
Aug 1, 1979·The Journal of Experimental Medicine·E L Morgan, W O Weigle
Jan 24, 1977·Biochimica Et Biophysica Acta·M FridkinZ Spirer
Nov 14, 1970·Nature·V A Najjar, K Nishioka
Aug 1, 1974·Journal of Immunological Methods·I A Ly, R I Mishell
Jun 4, 1971·Science·M Hoffmann, R W Dutton
Oct 1, 1971·Cellular Immunology·K Shortman, J Palmer

❮ Previous
Next ❯

Citations

Mar 1, 1985·Molecular Immunology·D R Burton
Dec 1, 1986·Immunopharmacology·E L MorganM V Hobbs
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E L MorganW O Weigle
Apr 1, 1983·The Journal of Experimental Medicine·M J BandaZ Werb
Oct 1, 1990·Immunological Reviews·W E Klinkert
Feb 12, 2014·Biochemistry. Biokhimii︠a︡·E V Navolotskaya
Jan 1, 1983·Annals of the New York Academy of Sciences·S SegalM Feldman
Jun 1, 1985·Clinical Immunology and Immunopathology·S N BreitR Penny
Nov 1, 1980·Immunology Today·M G Goodman
Jan 1, 1980·Journal of Supramolecular Structure·M L ThomanW O Weigle
Jan 1, 1980·Journal of Supramolecular Structure·E L Morgan, W O Weigle
Nov 1, 1986·Immunological Investigations·E L MorganW O Weigle
Nov 1, 1980·European Journal of Immunology·A J TrevesZ Fuks
Aug 1, 1986·European Journal of Immunology·C N BaxevanisM Papamichail
Jan 9, 2009·Analytical Chemistry·Xu-Wei ChenPurnendu K Dasgupta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.