Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC)

FEBS Letters
Yvonne SchrockClaudia A O Stuermer

Abstract

While the prion protein (PrP) is clearly involved in neuropathology, its physiological roles remain elusive. Here, we demonstrate PrP functions in cell-substrate interaction in Drosophila S2, N2a and HeLa cells. PrP promotes cell spreading and/or filopodia formation when overexpressed, and lamellipodia when downregulated. Moreover, PrP normally accumulates in focal adhesions (FAs), and its downregulation leads to reduced FA numbers, increased FA length, along with Src and focal adhesion kinase (FAK) activation. Furthermore, its overexpression elicits the formation of novel FA-like structures, which require intact reggie/flotillin microdomains. Altogether, PrP modulates process formation and FA dynamics, possibly via signal transduction involving FAK and Src.

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Citations

Mar 23, 2012·Molecular Biology of the Cell·Gonzalo P SolisClaudia A O Stuermer
Apr 1, 2014·Acta Biochimica Et Biophysica Sinica·Xiaowen YangChaoyang Li
Aug 21, 2013·Molecular Neurobiology·Franc LlorensJosé Antonio del Río
Nov 15, 2011·Cellular and Molecular Life Sciences : CMLS·Sandrine AlaisPascal Leblanc
Aug 25, 2015·European Journal of Cell Biology·Nikola HülsbuschClaudia A O Stuermer
May 4, 2013·Journal of Neurochemistry·Franc LlorensJosé A del Río
Nov 5, 2014·Frontiers in Cell and Developmental Biology·Sophie HalliezVincent Béringue
Nov 10, 2009·Trends in Cell Biology·Claudia A O Stuermer
Mar 5, 2013·International Journal of Molecular Sciences·Gonzalo P SolisVladimir L Katanaev
Sep 4, 2016·Journal of Cell Science·Ladan AminGiuseppe Legname
Sep 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Flavio H BeraldoVilma R Martins
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrew J NicollJohn Collinge
Jan 11, 2011·Journal of Neurochemistry·Claudia A O Stuermer
Sep 3, 2020·Cellular and Molecular Life Sciences : CMLS·Fatima-Zohra BoufrouraFatima Djouadi
Sep 17, 2020·International Journal of Molecular Sciences·Mariana Brandão PradoMarilene Hohmuth Lopes
Apr 2, 2010·ACS Applied Materials & Interfaces·Miho NakamuraKimihiro Yamashita
Jul 15, 2015·Journal of Cell Science·Dion D RichardsonMar Fernandez-Borja

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