Regulation of folliculogenesis in the cycling rhesus monkey: selection of the dominant follicle

Endocrinology
A L GoodmanG D Hodgen

Abstract

To identify factors regulating the initiation of follicle growth in adult primates, the ovarian cycle of sexually mature rhesus monkeys was interrupted by surgical ablation of the preovulatory follicle or functioning corpus luteum (CL). In 10 of 10 animals, cautery of the largest visible follicle on Day 8-12 of the cycle blocked ovulation, and in all but one abolished the expected midcycle surges of gonadotropin secretion. In 8 monkeys of this group, surges of LH and FSH release occurred 12.4 +/- 0.9 days (d) (mean +/- SE) after cautery, coincident with elevations in serum estrogens, and succeeded by typical luteal phase patterns of circulating progesterone (P). No gonadotropin or estrogen surges were observed during the next 32 days of sampling in the remaining pair, despite visible new vesicular follicles. Removal of the CL in 5 of 5 monkeys 4-6 days after the midcycle LH surge was followed by a reduction in serum P to less than 0.25 ng/ml within 24 h and by the onset of menses within 3-4 days. After luteectomy in 4 of the 5 animals, preoperative levels of LH and FSH were maintained until 12.8 +/- 0.9 days, when typical surges of gonadotropin secretion occurred, followed by a normal luteal phase pattern of P. The fifth luteec...Continue Reading

Citations

Apr 1, 1989·Journal of in Vitro Fertilization and Embryo Transfer : IVF·J BlanksteinM M Quigley
Dec 1, 1986·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·S JayaramanA R Sheth
Jul 1, 1979·Journal of Steroid Biochemistry·L Schenkel-HulligerP Bischof
Jan 1, 1987·Journal of Steroid Biochemistry·G S diZeregaG Westhof
Jan 1, 1989·Journal of Steroid Biochemistry·A F GlasierS G Hillier
Oct 1, 1980·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P F Van Look, D T Baird
Apr 1, 1984·Theriogenology·M A Driancourt, E Palmer
Aug 1, 1980·Molecular and Cellular Endocrinology·J R SchreiberG F Erickson
Jan 1, 1980·Psychoneuroendocrinology·W B Cutler, C R Garcia
Nov 1, 1984·American Journal of Human Genetics·D R MattisonJ D Schulman
Oct 1, 1979·Psychoneuroendocrinology·W B CutlerA M Krieger
Jan 1, 1988·Annals of the New York Academy of Sciences·L HambergerA Sjögren
Feb 1, 1987·Baillière's Clinical Endocrinology and Metabolism·D L HealyP A Rogers
Feb 1, 1986·Clinics in Endocrinology and Metabolism·S A Tonetta, G S diZerega
Nov 1, 1978·Clinics in Endocrinology and Metabolism·G T Ross, M B Lipsett
Feb 1, 1997·Endocrine Reviews·B C Fauser, A M Van Heusden
Jan 17, 2019·The Journal of Clinical Endocrinology and Metabolism·Bob Z SunNatalie D Shaw
Mar 14, 2012·PloS One·Claudia Rudolf von RohrCarel P van Schaik
Jan 1, 1987·American Journal of Primatology·Donald J DierschkeRichard C Wolf
Jan 1, 1987·American Journal of Primatology·Reinhold J HutzRichard C Wolf
Jan 1, 1987·American Journal of Primatology·Varadaraj ChandrashekarRichard C Wolf
Nov 1, 1982·The American Journal of Physiology·A L Goodman, G D Hodgen
May 1, 1981·The American Journal of Physiology·J A ReskoE Knobil
Oct 1, 1982·The American Journal of Physiology·A L GoodmanG D Hodgen

Related Concepts

Anthropoidea
Cell Differentiation Process
Structure of Corpus Luteum of Ovary
Estrogen Effect
Follicle Stimulating Hormone
Atretic Follicle
Luteozyman
Macaca mulatta
Menstruation
Ovulation

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