Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins
Abstract
G protein-coupled receptors (GPCRs) are involved in many biological processes. Therefore, GPCR function is tightly controlled both at receptor level and at the level of signalling components. Well-known mechanisms by which GPCR function can be regulated comprise desensitization/resensitization processes and GPCR up- and downregulation. GPCR function can also be regulated by several proteins that directly interact with the receptor and thereby modulate receptor activity. An additional mechanism by which receptor signalling is regulated involves an emerging class of proteins, the so-called regulators of G protein signalling (RGS). In this review we will describe some of these control mechanisms in more detail with some specific examples in the cardiovascular system. In addition, we will provide an overview on RGS proteins and the involvement of RGS proteins in cardiovascular function.
References
Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells
Citations
Identification of ligands targeting RGS proteins high-throughput screening and therapeutic potential
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