Regulation of gap junction connexins in the endometrium during early pregnancy

Cell and Tissue Research
R Grümmer, E Winterhager

Abstract

In mammalian species embryo implantation into uterine tissue is restricted to a limited time period, the receptive phase. For successful implantation appropriate differentiation of the receptive endometrium is under the control of ovarian steroid hormones. In addition, locally acting embryonic signals are needed to modulate the maternal environment before invasion of the trophoblast is permitted. The expression pattern of gap junction channel proteins, connexins (cx), is directly related to this process. In rodents as well as in rabbit and humans the receptive endometrium is characterized by a lack of such cell-to-cell communication channels. In the rat endometrium cx26 is suppressed in the epithelium and cx43 in the stromal compartment by maternal progesterone, a phenomenon that can be observed similarly in human endometrium. Experimental approaches revealed that both connexin genes react very sensitively to progesterone and estrogen treatment. In rat and rabbit connexin expression is induced locally in the endometrium in response to the implanting blastocyst. In both species this induction of connexins can be mimicked by a traumatic stimulus. In conclusion, suppression of connexin expression in the endometrium is a characteri...Continue Reading

Citations

Jun 6, 2002·Japanese Journal of Cancer Research : Gann·Toshio Kuroki, Manfred F Rajewsky
Nov 20, 2004·Obstetrics and Gynecology Clinics of North America·Pinar H Kodaman, Hugh S Taylor
Oct 18, 2011·Biochimica Et Biophysica Acta·Ilaria PotolicchioPaolo Meda
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·S Sunder, E A Lenton
Jul 28, 2012·Biology of Reproduction·Remington Lee Nevin
Aug 1, 2018·International Journal of Molecular Sciences·Susanne Grund, Ruth Grümmer
Jan 16, 2007·Canadian Journal of Physiology and Pharmacology·Ewa BorowczykAnna T Grazul-Bilska
Oct 21, 2011·Physiological Reviews·Domenico BoscoPaolo Meda
May 14, 2021·Physiological Research·M KnížeT Fait

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