Regulation of gene expression by FSP27 in white and brown adipose tissue.

BMC Genomics
De LiJianli Sang

Abstract

Brown and white adipose tissues (BAT and WAT) play critical roles in controlling energy homeostasis and in the development of obesity and diabetes. The mouse Fat-Specific protein 27 (FSP27), a member of the cell death-inducing DFF45-like effector (CIDE) family, is expressed in both BAT and WAT and is associated with lipid droplets. Over-expression of FSP27 promotes lipid storage, whereas FSP27 deficient mice have improved insulin sensitivity and are resistant to diet-induced obesity. In addition, FSP27-deficient white adipocytes have reduced lipid storage, smaller lipid droplets, increased mitochondrial activity and a higher expression of several BAT-selective genes. To elucidate the molecular mechanism by which FSP27 controls lipid storage and gene expression in WAT and BAT, we systematically analyzed the gene expression profile of FSP27-deficient WAT by microarray analysis and compared the expression levels of a specific set of genes in WAT and BAT by semi-quantitative real-time PCR analysis. BAT-selective genes were significantly up-regulated, whereas WAT-selective genes were down-regulated in the WAT of FSP27-deficient mice. The expression of the BAT-selective genes was also dramatically up-regulated in the WAT of leptin/FS...Continue Reading

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Citations

Jan 7, 2014·Amino Acids·Wei-Qiang ChenGert Lubec
Oct 21, 2015·Genomics Data·Li XuLinkang Zhou
Sep 27, 2014·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hongqiang LiZaiqing Yang
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Oct 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Xiaodong ZhangJun Liu
Mar 22, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhuo-Hui LuoXiao-Ling Shen

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Methods Mentioned

BETA
PCR
chips
GTPase

Software Mentioned

Gene Set Enrichment Analysis ( GSEA )
Gene Set Enrichment Analysis ( GSEA
Quantity One
GSEA
BLAST
Graph Pad Prism
GraphPad
Affymetrix GeneChip Operating Software ( GCOS )

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