PMID: 6975761Nov 15, 1981Paper

Regulation of gene expression by tumor promoters. III. Complementation of the developmental program in myeloid leukemic cells by regulating mRNA production and mRNA translation

International Journal of Cancer. Journal International Du Cancer
B Hoffman-LiebermannL Sachs

Abstract

Regulation of gene expression has been analysed in different clones of mouse myeloid leukemic cells treated with the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate (TPA), the macrophage- and granulocyte-inducing protein MGI, and combined treatment with TPA and MGI. Two-dimensional gel electrophoresis was used to measure changes in the rate of synthesis of specific proteins and in the amount of corresponding translatable mRNAs assayed in the reticulocyte cell-free translation system. TPA induced different subsets of differentiation-associated protein changes in the different clones and the degree of response to TPA was not necessarily related to the degree of response to MGI. It is shown that TPA can induce protein changes either by inducing the synthesis of new mRNA, by increasing or decreasing the amount of pre-existing mRNA, or by modulating the translation of a constant amount of mRNA. Combined treatment with TPA and MGI resulted in an enhancement of protein changes induced by MGI or TPA alone and induced differentiation-associated protein changes not induced by either compound separately in differentiation-defective clones. This complementation of gene expression appeared to be due to each compound inducing functions ...Continue Reading

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J I Azumi, L Sachs
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Aug 15, 1978·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E Huberman, M F Callaham
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G RoveraC Damsky
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Aug 1, 1976·European Journal of Biochemistry·H R Pelham, R J Jackson
Dec 1, 1969·Journal of Cellular Physiology·Y Ichikawa
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E FibachL Sachs
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S M Landfear, H F Lodish
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·A Falk, L Sachs
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L Cohen, L Sachs
Jun 15, 1980·International Journal of Cancer. Journal International Du Cancer·J LotemL Sachs

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Citations

Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Apr 1, 1982·Journal of Cellular Physiology·G Symonds, L Sachs
Apr 15, 1983·International Journal of Cancer. Journal International Du Cancer·R SimantovL Sachs
Apr 15, 1984·International Journal of Cancer. Journal International Du Cancer·D A Chow
Aug 21, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L Sachs
Dec 1, 1986·Cell Biophysics·L Sachs
Feb 1, 2003·The Journal of General Virology·Dana N MitzelMichele E Hardy

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