Regulation of gene expression in vertebrate skeletal muscle

Experimental Cell Research
Jaime J Carvajal, Peter W J Rigby

Abstract

During embryonic development the integration of numerous synergistic signalling pathways turns a single cell into a multicellular organism with specialized cell types and highly structured, organized tissues. To achieve this, cells must grow, proliferate, differentiate and die according to their spatiotemporal position. Unravelling the mechanisms by which a cell adopts the correct fate in response to its local environment remains one of the fundamental goals of biological research. In vertebrates skeletal myogenesis is coordinated by the activation of the myogenic regulatory factors (MRFs) in response to signals that are interpreted by their associated regulatory elements in different precursor cells during development. The MRFs trigger a cascade of transcription factors and downstream structural genes, ultimately resulting in the generation of one of the fundamental histotypes. In this review we discuss the regulation of the different MRFs in relation to their position in the myogenic cascade, the changes in the general transcriptional machinery during muscle differentiation and the emerging importance of miRNA regulation in skeletal myogenesis.

References

Nov 1, 1992·Molecular and Cellular Biology·S J TapscottH Weintraub
Mar 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C L PinS F Konieczny
Aug 8, 1997·Biochemical and Biophysical Research Communications·C M Kerkvliet, T J Hinterberger
Apr 24, 2002·Developmental Biology·Jennifer C J ChenDavid J Goldhamer
Aug 26, 2004·Developmental Biology·Peter S ZammitJonathan R Beauchamp
Sep 24, 2004·Nature·Lina Kassar-DuchossoyShahragim Tajbakhsh
Aug 21, 2007·Genes & Development·Maria Divina E Deato, Robert Tjian
Oct 15, 2008·Molecular Cell·Maria Divina E DeatoRobert Tjian
Oct 16, 2008·Developmental Cell·Ping HuRobert Tjian
Jun 18, 2009·Developmental Cell·Ramkumar SambasivanShahragim Tajbakhsh
Jun 18, 2009·Developmental Cell·Itamar HarelEldad Tzahor
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Colin G CristMargaret Buckingham

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Citations

Jan 29, 2016·Nucleic Acids Research·Amaresh C PandaMyriam Gorospe
Jan 13, 2016·Epigenomics·Lauren BuckleyMelanie Ehrlich
Sep 11, 2010·Experimental Cell Research·Keren Bismuth, Frédéric Relaix
Jun 12, 2013·The FEBS Journal·Natalia MoncautJaime J Carvajal
Jun 5, 2015·Human Molecular Genetics·Sruti ChandraMelanie Ehrlich
Apr 15, 2014·BioMed Research International·Germana FalconeFabio Martelli
Feb 15, 2011·Biochimica Et Biophysica Acta·Christopher von RoretzImed-Eddine Gallouzi
Oct 26, 2016·Advances in Biological Regulation·Giulia RamazzottiMatilde Y Follo
Dec 1, 2012·Stem Cells Translational Medicine·Karlijn J WilschutHarold S Bernstein
Mar 30, 2019·PloS One·Rachel MunkAmaresh C Panda
Jul 14, 2019·Journal of Muscle Research and Cell Motility·Fiona C Wardle

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