Regulation of gene expression is linked to life span in adult Drosophila.

Genetics
B Rogina, S L Helfand

Abstract

Examination of gene expression and aging in adult Drosophila reveals that the expression of some genes is regulated by age-dependent mechanisms. Genetic mutations, Hyperkinetic and Shaker, which are known to shorten life span through an acceleration of the aging process, were used to study the expression of an enhancer trap marked gene. The temporal pattern of expression for such a marked gene shows scaling with respect to life span; it is altered in direct proportion to the life expectancy of the adult animal. This demonstrates that expression of this gene is controlled through mechanisms coupled to physiologic as opposed to chronologic age. Results provide direct evidence for linkage between the regulation of gene expression and life span and establish a model system for the genetic analysis of aging.

Citations

Feb 12, 2002·Nature Reviews. Genetics·Stephen L Helfand, Sharon K Inouye
Aug 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Johannes H BauerStephen L Helfand
Sep 1, 2005·Age·Luc Poirier, Laurent Seroude
Oct 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Tower
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·B RoginaS L Helfand
Dec 13, 2005·Ageing Research Reviews·Qihua TanKaare Christensen
May 15, 2002·Current Biology : CB·Scott D PletcherLinda Partridge
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Dec 18, 2001·Mechanisms of Development·Barry Hoopengardner, Stephen L Helfand
May 12, 2009·Mechanisms of Ageing and Development·Matthew A BedoukianJennifer Park

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