PMID: 15377264Sep 21, 2004Paper

Regulation of gene expression via triple helical formations

Biochemistry. Biokhimii︠a︡
V KarympalisH Carageorgiou

Abstract

Triplex-forming oligonucleotides (TFOs) are a challenging and very promising subject in modern biochemistry and molecular genetics. Over the last decade, several studies have stated that TFOs: a) can bind to DNA in a sequence-specific manner; b) can provoke DNA repair and recombination in mammalian cells, and c) can be a very effective biological tool in embryonic and oncogenic research on gene expression pathways. Herein we review the basic modes in which TFOs exist, their gene-regulation properties, as well as the obstacles that should be overcome before they become useful in clinical practice (chemotherapy and/or gene therapy).

Citations

Sep 14, 2010·Organic & Biomolecular Chemistry·Simon R GerrardTom Brown

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