Regulation of glomerular and proximal tubule renin mRNA by chronic changes in dietary NaCl

The American Journal of Physiology
J E TankO W Moe

Abstract

Renal adaptations to chronic changes in dietary NaCl and extracellular fluid volume involve both glomerular and tubular mechanisms that result in preservation of glomerular filtration rate and modifications of renal tubular transport to secure external NaCl balance. Although the systemic renin-angiotensin system (RAS) mediates some of these responses, the possible contributions of local glomerular and proximal tubule RASs in these adaptations have not been examined. Thus, in this study, glomeruli and proximal tubules were microdissected from rats adapted to high (4.0%), normal (0.5%), or low (0.01%)-NaCl diets, and renin mRNA was measured using quantitative competitive reverse transcription-polymerase chain reaction. After 4 days of the diets, glomerular renin mRNA abundance was increased 100% by the low-NaCl diet (P < 0.05) and suppressed 50% (P < 0.01) by the high NaCl diet compared with controls. Renin mRNA in proximal tubules was stimulated 230% (P < 0.05) by the low-NaCl diet and tended to be suppressed (68% decrease, not significant) by the high-NaCl diet. When the high-NaCl diet was continued for 2 wk, proximal tubule renin mRNA was suppressed by 89% (P < 0.05). This study provides evidence that glomerular and proximal t...Continue Reading

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Citations

Mar 19, 2003·Current Hypertension Reports·L Gabriel NavarMinolfa Prieto-Carrasquero
Sep 20, 2012·Pflügers Archiv : European journal of physiology·Minolfa C PrietoL Gabriel Navar
Feb 24, 2001·American Journal of Physiology. Renal Physiology·G J WehbiK D Burns
May 5, 2005·American Journal of Physiology. Renal Physiology·Minolfa C Prieto-CarrasqueroL Gabriel Navar
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·A CharbonneauM G Brunette

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