Regulation of glomerulotubular balance. I. Impact of dopamine on flow-dependent transport.

American Journal of Physiology. Renal Physiology
Zhaopeng DuTong Wang

Abstract

In response to volume expansion, locally generated dopamine decreases proximal tubule reabsorption by reducing both Na/H-exchanger 3 (NHE3) and Na-K-ATPase activity. We have previously demonstrated that mouse proximal tubules in vitro respond to changes in luminal flow with proportional changes in Na(+) and HCO(3)(-) reabsorption and have suggested that this observation underlies glomerulotubular balance. In the present work, we investigate the impact of dopamine on the sensitivity of reabsorptive fluxes to changes in luminal flow. Mouse proximal tubules were microperfused in vitro at low and high flow rates, and volume and HCO(3)(-) reabsorption (J(v) and J(HCO3)) were measured, while Na(+) and Cl(-) reabsorption (J(Na) and J(Cl)) were estimated. Raising luminal flow increased J(v), J(Na), and J(HCO3) but did not change J(Cl). Luminal dopamine did not change J(v), J(Na), and J(HCO3) at low flow rates but completely abolished the increments of Na(+) absorption by flow and partially inhibited the flow-stimulated HCO(3)(-) absorption. The remaining flow-stimulated HCO(3)(-) absorption was completely abolished by bafilomycin. The DA1 receptor blocker SCH23390 and the PKA inhibitor H89 blocked the effect of exogenous dopamine and p...Continue Reading

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Citations

Feb 21, 2014·American Journal of Physiology. Renal Physiology·Mohammad M Al-batainehNúria M Pastor-Soler
Feb 5, 2015·American Journal of Physiology. Renal Physiology·Zhaopeng DuTong Wang
Jan 17, 2015·Current Opinion in Nephrology and Hypertension·Ming-Zhi Zhang, Raymond C Harris
Oct 24, 2014·American Journal of Physiology. Renal Physiology·Riley Charles EnnisVan Anthony M Villar
Apr 20, 2018·American Journal of Physiology. Renal Physiology·Fara SaezJeffrey L Garvin
Dec 2, 2020·International Journal of Molecular Sciences·Victor J MartinezAndrew C Tiu

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