Regulation of glucose tolerance in patients after liver transplantation: impact of cyclosporin versus tacrolimus therapy

Transplantation
T KonradP Neuhaus

Abstract

We investigated the factors regulating glucose homeostasis in 10 healthy (control) subjects, as well as in stable, long-term, liver-grafted patients receiving monotherapy in the form of either cyclosporin A (n=10) or tacrolimus (n=10). We measured insulin sensitivity, first- and second-phase insulin secretion, with a minimal modeling technique based on the analysis of glucose, insulin, and C-peptide profiles during frequently sampled intravenous glucose tolerance tests (FSIGTT). Proinsulin levels, as a marker of beta-cell dysfunction, were measured in the fasting state and during FSIGTT. Glucose and insulin concentrations before and after glucose loading did not differ in liver transplant patients and in control subjects. Fasting C-peptide levels in both liver-grafted groups were higher than in healthy subjects and remained elevated during FSIGTT (P<0.05). Intravenous glucose tolerance [(K(G)), i.e. the slope of the regression of logarithm of the blood glucose concentrations vs. time], insulin sensitivity, and first-phase insulin secretion did not differ in liver-grafted groups and healthy subjects. Second-phase insulin secretion was about 56% higher in liver-grafted patients than in controls (P<0.05). Body mass index was the o...Continue Reading

References

Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MeyerW H Caselmann
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J BrownH C Thomas
Aug 1, 1992·AJR. American Journal of Roentgenology·J L ChezmarJ M Henderson
Apr 1, 1989·Diabetes·S L GillisonD L Curry
Sep 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M HendersonW D Warren
May 1, 1988·The Journal of Clinical Investigation·D KelleyM Berger
Sep 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A FrancavillaT E Starzl
Dec 1, 1985·Diabetes·J F YaleE B Marliss
Sep 20, 1973·The New England Journal of Medicine·E J RayfieldW R Beisel
Jul 1, 1984·Diabetologia·A AnderssonA Schnell
Aug 15, 1994·Transplantation·R M JindalC M Miller
Oct 1, 1993·Transplantation·J Tabasco-MinguillanT E Starzl
Feb 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A HadengueS Erlinger
Mar 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NavasaJ Rodés
Mar 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M Henderson
Aug 15, 1997·The Journal of Clinical Investigation·G PerseghinL Luzi
Oct 23, 1997·The Journal of Clinical Investigation·F DelaunayS Okret
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S PetridesH Lambeth

❮ Previous
Next ❯

Citations

Mar 20, 2003·Transplantation Proceedings·G SaharB A Vidne
Mar 26, 2004·Transplantation Proceedings·S BeckebaumC E Broelsch
Feb 16, 2005·The American Journal of the Medical Sciences·Pablo F Mora
Nov 30, 2006·Diabetes & Metabolism·A Penfornis, S Kury-Paulin
Oct 13, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jacques PirenneFrederik Nevens
Feb 24, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Martin StockmannPeter Neuhaus
Oct 13, 2011·British Journal of Clinical Pharmacology·Lara Aygen ØzbayKaj Anker Jørgensen
Sep 26, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·L A OzbayK A Jørgensen
Jul 1, 2005·Metabolism: Clinical and Experimental·Hermann J KisslerPaul O Schwille
Feb 24, 2007·Annales d'endocrinologie·M-C VantyghemC Noël
Aug 12, 2016·Journal of Diabetes Investigation·Mengjuan XueXin Gao
Feb 4, 2016·World Journal of Hepatology·Mustafa S AschaIbrahim A Hanouneh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.