PMID: 15235326Jul 6, 2004Paper

Regulation of GLUT4 gene expression during exercise

Medicine and Science in Sports and Exercise
Burton Holmes, G Lynis Dohm

Abstract

Glucose transport into muscle is important for the maintenance of normoglycemia. Thus, understanding mechanisms that regulate expression of GLUT4, the main glucose transporter in skeletal muscle, is important to identify targets for the treatment of diabetes. Exercise increases the expression of GLUT4 mRNA and protein, and we have been investigating the mechanisms involved. Transcription of the GLUT4 gene is transiently activated after an acute bout of exercise and GLUT4 protein can be increased as much as two- to threefold after a few days of repeated exercise bouts. Studies of the GLUT4 promoter have identified two sets of DNA sequences that are important for metabolic regulation and also for increased transcription of the gene in response to exercise. These DNA elements have been shown to bind the transcription factors myocyte enhancer factor 2 (MEF2) and GLUT4 enhancer factor (GEF). The mechanisms that activate these proteins remain one of the important areas of research in this field. Signals that link muscle contraction to the activation of transcription factors (MEF2, GEF) involved in increased expression of GLUT4 during exercise is another area needing further research. Two signals that show promise are changes in the e...Continue Reading

References

Jan 1, 1992·The American Journal of Physiology·K J RodnickJ O Holloszy
Dec 1, 1993·The American Journal of Physiology·P D Neufer, G L Dohm
Oct 6, 1995·The Journal of Biological Chemistry·A L Olson, J E Pessin
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·S IkemotoO Ezaki
Jan 1, 1993·The American Journal of Physiology·J M RenJ O Holloszy
Jan 12, 1996·The Journal of Biological Chemistry·D StapletonB E Kemp
Nov 1, 1995·Journal of Applied Physiology·E A Gulve, R J Spina
Dec 1, 1995·Journal of Applied Physiology·J A HoumardG L Dohm
Nov 5, 1997·Biochemical and Biophysical Research Communications·N TsunodaO Ezaki
Feb 12, 1998·Biochemical and Biophysical Research Communications·O Ezaki
Mar 25, 1999·Acta Physiologica Scandinavica·C H KuoJ L Ivy
Feb 15, 2000·The Journal of Biological Chemistry·F J NayaE N Olson
Feb 16, 2000·Biochemical and Biophysical Research Communications·N TsunodaO Ezaki
Aug 18, 2001·Journal of Applied Physiology·D ZhengG L Dohm
Mar 22, 2002·Biochemical and Biophysical Research Communications·Paul S MacLeanG Lynis Dohm
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Edward O OjukaJohn O Holloszy

❮ Previous
Next ❯

Citations

Feb 14, 2014·Cell Stress & Chaperones·Philip L HooperLaszlo Vigh
Dec 20, 2012·ISRN Endocrinology·Lisa Stehno-Bittel
Oct 14, 2006·Journal of Bioenergetics and Biomembranes·Richmond MuimoAnil Mehta
Apr 7, 2007·Omics : a Journal of Integrative Biology·Ji ChenDavid J States
Oct 5, 2010·The International Journal of Biochemistry & Cell Biology·Yuewen ChenDahai Zhu
Oct 3, 2008·Pediatric Diabetes·Jaime S Rosa, Pietro R Galassetti
Aug 11, 2005·Metabolism: Clinical and Experimental·Tracy BaynardJill A Kanaley
Jun 7, 2015·Cardiovascular Diabetology·April L Darrow, Ralph V Shohet
Apr 4, 2007·Cell Metabolism·Shaohui Huang, Michael P Czech
Feb 27, 2013·Arquivos brasileiros de endocrinologia e metabologia·Patricia Ebersbach-SilvaPatricia Monteiro Seraphim
Nov 25, 2011·Molecular Biology of the Cell·Rob U OnyenwokeJay E Brenman
Aug 16, 2005·Journal of Applied Physiology·Thomas L HilderLee M Graves
Jul 24, 2008·American Journal of Physiology. Endocrinology and Metabolism·James A H SmithEdward O Ojuka
Apr 13, 2012·American Journal of Physiology. Endocrinology and Metabolism·Edward O OjukaJames A H Smith
Dec 7, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H J GreenJ Ouyang
Jul 30, 2005·Journal of Applied Physiology·Nils HalbergFlemming Dela
Mar 20, 2019·American Journal of Physiology. Endocrinology and Metabolism·Jin-Ho KohSurendra Dasari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.