Regulation of glycan structures in animal tissues: transcript profiling of glycan-related genes.

The Journal of Biological Chemistry
Alison V NairnKelley W Moremen

Abstract

Glycan structures covalently attached to proteins and lipids play numerous roles in mammalian cells, including protein folding, targeting, recognition, and adhesion at the molecular or cellular level. Regulating the abundance of glycan structures on cellular glycoproteins and glycolipids is a complex process that depends on numerous factors. Most models for glycan regulation hypothesize that transcriptional control of the enzymes involved in glycan synthesis, modification, and catabolism determines glycan abundance and diversity. However, few broad-based studies have examined correlations between glycan structures and transcripts encoding the relevant biosynthetic and catabolic enzymes. Low transcript abundance for many glycan-related genes has hampered broad-based transcript profiling for comparison with glycan structural data. In an effort to facilitate comparison with glycan structural data and to identify the molecular basis of alterations in glycan structures, we have developed a medium-throughput quantitative real time reverse transcriptase-PCR platform for the analysis of transcripts encoding glycan-related enzymes and proteins in mouse tissues and cells. The method employs a comprehensive list of >700 genes, including e...Continue Reading

References

Nov 1, 1991·Glycobiology·H Schachter
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
May 1, 1988·Immunological Investigations·J A MortonR I Vanhegan
Jan 1, 1985·Annual Review of Biochemistry·R Kornfeld, S Kornfeld
Oct 20, 1995·Science·V E VelculescuK W Kinzler
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·K TerayamaT Kawasaki
Dec 1, 1996·Nature Biotechnology·D J LockhartE L Brown
Aug 26, 1998·The Journal of Biological Chemistry·K UchimuraT Muramatsu
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·K TakamiyaK Furukawa
Oct 22, 1998·Acta Anatomica·I BrockhausenW Kuhns
Jan 23, 1999·Nature Genetics·R J LipshutzD J Lockhart
Jun 22, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J W DennisC E Warren
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Aug 19, 2000·Current Topics in Developmental Biology·J M OrthA L Laslett
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 6, 2002·Molecular and Cellular Neurosciences·Claudia SennMelitta Schachner
Sep 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jianjun ChenSan Ming Wang
Jan 10, 2003·Nucleic Acids Research·Maximilian DiehnAsh A Alizadeh
Feb 13, 2003·Nucleic Acids Research·Rafael A IrizarryTerence P Speed
Mar 6, 2003·Neuroscience Letters·Christian RamakersAntoon F M Moorman
Apr 5, 2003·Annual Review of Biochemistry·John B Lowe, Jamey D Marth

❮ Previous
Next ❯

Citations

Dec 10, 2013·Analytical Chemistry·Muchena J KailemiaI Jonathan Amster
Jun 1, 2012·Glycoconjugate Journal·Vlatka ZoldošGordan Lauc
Oct 12, 2012·Glycoconjugate Journal·Leyla GasimliRobert J Linhardt
Jun 19, 2012·Clinical Epigenetics·Tomislav HorvatGordan Lauc
Aug 13, 2013·Neurochemistry International·Adriana R RinflerchPablo F Argibay
Sep 5, 2009·ACS Chemical Biology·Lakshmi Krishnamoorthy, Lara K Mahal
Mar 28, 2013·Chemical Reviews·William R AlleyMilos V Novotny
Jun 23, 2012·Nature Reviews. Molecular Cell Biology·Kelley W MoremenAlison V Nairn
Sep 17, 2009·Molecular BioSystems·Richard D Cummings
Oct 20, 2010·Molecular BioSystems·Gordan Lauc, Vlatka Zoldoš
Nov 26, 2008·Journal of Lipid Research·Alfred H MerrillMay Dongmei Wang
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Praveen AgrawalLara K Mahal
Nov 16, 2013·Nature Chemical Biology·Margreet A Wolfert, Geert-Jan Boons
Jan 1, 2013·Cells·Sylvain JulienPhilippe Delannoy
Jul 16, 2015·Expert Opinion on Biological Therapy·Martina Dicker, Richard Strasser
Aug 11, 2011·FEBS Letters·Pieter P Jacobs, Robert Sackstein
Mar 13, 2016·Biochimica Et Biophysica Acta·Joanne ChiaFrederic Bard
Jul 15, 2009·Immunological Reviews·Juan J García-Vallejo, Yvette van Kooyk
Mar 15, 2016·Pflügers Archiv : European journal of physiology·Xiaoqian QianGuangping Chen
Jun 4, 2010·Biotechnology and Bioengineering·Danny Chee Furng WongMiranda Gek Sim Yap
Mar 3, 2012·Annals of the New York Academy of Sciences·Takashi AngataNaoyuki Taniguchi
Jun 23, 2015·Molecular Ecology·Longfei ShuKatja Räsänen

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.