PMID: 6402474Jan 1, 1983Paper

Regulation of glycogenolysis in human muscle in response to epinephrine infusion

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
D ChasiotisE Hultman

Abstract

The regulation of glycogenolysis in human muscle during epinephrine infusion has been investigated. The content of cAMP in resting muscle was 2.7 +/- 0.7 (SD) mumol . kg dry muscle-1 and increased threefold during the first 5 min of infusion. Total glycogen phosphorylase and glycogen synthase activities were unchanged during the infusion. The proportion of phosphorylase in the a form in the basal state was estimated to be at least 22.5% and during infusion 80-90%. During infusion, synthase I activity decreased. The muscle glycogen content was 340 mmol . kg dry wt-1 and decreased during the first 2 min of infusion at a rate of 11.0 mmol glycosyl units . kg dry wt-1 . min-1. Prolonged infusion resulted in a much lower glycogenolytic rate, even though most of the phosphorylase was still in the a form. Accumulation of hexose monophosphates and lactate followed the changes in glycogen. It was concluded that despite the almost total transformation of phosphorylase to the a form, the in vivo activity was maintained at a low level. It is suggested that this may be due to a low concentration of inorganic phosphate at the active site of the enzyme.

Citations

Jan 1, 1986·Acta Medica Scandinavica. Supplementum·S E KjeldsenK Gautvik
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·M Jensen-UrstadK Sahlin
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·M G Hollidge-HorvatG J Heigenhauser
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Gregory J CrowtherKevin E Conley
Jan 19, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C SaleJ Corbett
Mar 10, 2012·Diabetes·Rasmus S BiensøJørgen F P Wojtaszewski
Apr 30, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Abram Katz, Håkan Westerblad
Jul 1, 1990·Acta Physiologica Scandinavica·J M RenE Hultman
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·J GórskiJ Rutkiewicz
Jan 1, 1984·European Journal of Applied Physiology and Occupational Physiology·G A GaesserB P Gardner
Feb 1, 1984·Acta Physiologica Scandinavica·E BlomstrandB Ekblom
Feb 26, 1998·Journal of Applied Physiology·M A FebbraioM Hargreaves
Mar 10, 1999·The American Journal of Physiology·D Constantin-TeodosiuP L Greenhaff
Mar 24, 2000·Medicine and Science in Sports and Exercise·D A SchneiderG C Gass
Aug 4, 1998·The American Journal of Physiology·R A HowlettL L Spriet
Oct 20, 2001·Journal of Applied Physiology·J W Rush, L L Spriet
Sep 25, 2015·The Journal of Physiology·Simeon P Cairns, Fabio Borrani
Jan 16, 2014·CJEM·Subramanian SenthilkumaranPonniah Thirumalaikolundusubramanian
Feb 12, 1998·The American Journal of Physiology·D LaurentG I Shulman
Apr 1, 1997·The American Journal of Physiology·J JensenO Brørs
Feb 16, 2006·American Journal of Physiology. Endocrinology and Metabolism·Cynthia C GreenbergMatthew J Brady
Aug 6, 2004·The Proceedings of the Nutrition Society·Jakob N Nielsen, Jørgen F P Wojtaszewski
Feb 16, 1987·European Journal of Biochemistry·R A ChallissE A Newsholme
Mar 3, 2009·The Biochemical Journal·Niels OrtenbladKent Sahlin
Jan 1, 1984·European Journal of Applied Physiology and Occupational Physiology·P A Tesch, J Karlsson
May 15, 1996·Experientia·H Schmidt, G Kamp
Jul 17, 2003·Acta Physiologica Scandinavica·J N Nielsen, E A Richter
Jan 1, 1995·The American Journal of Physiology·D A FryburgE J Barrett
May 1, 1985·The American Journal of Physiology·G Ahlborg
Mar 1, 1991·The American Journal of Physiology·M K SpencerI Raz
May 1, 1991·The American Journal of Physiology·P L GreenhaffE Hultman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.