Regulation of Golgi Cisternal Progression by Ypt/Rab GTPases

Developmental Cell
Jane J KimN Segev

Abstract

Current models entail that transport through the Golgi-the main sorting compartment of the cell-occurs via cisternal progression/maturation and that Ypt/Rab GTPases regulate this process. However, there is very limited evidence that cisternal progression is regulated, and no evidence for involvement of Ypt/Rab GTPases in such a regulation. Moreover, controversy about the placement of two of the founding members of the Ypt/Rab family, Ypt1 and Ypt31, to specific Golgi cisternae interferes with addressing this question in yeast, where cisternal progression has been extensively studied. Here, we establish the localization of Ypt1 and Ypt31 to opposite faces of the Golgi: early and late, respectively. Moreover, we show that they partially overlap on a transitional compartment. Finally, we determine that changes in Ypt1 and Ypt31 activity affect Golgi cisternal progression, early-to-transitional and transitional-to-late, respectively. These results show that Ypt/Rab GTPases regulate two separate steps of Golgi cisternal progression.

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Citations

Apr 12, 2016·Frontiers in Cell and Developmental Biology·Jane J KimNava Segev
Jun 3, 2016·Frontiers in Cell and Developmental Biology·Stephanie BrunetMichael Sacher
Oct 16, 2016·Molecular Microbiology·Z SchultzhausB D Shaw
Nov 8, 2017·The Journal of Cell Biology·Laura L ThomasJ Christopher Fromme
Nov 8, 2018·PloS One·Jorge Y Martínez-Márquez, Mara C Duncan
Jun 26, 2020·ELife·Jason C Casler, Benjamin S Glick
Aug 27, 2019·Frontiers in Cell and Developmental Biology·Areti Pantazopoulou, Benjamin S Glick
Aug 7, 2020·ELife·Quentin VagnePierre Sens
Nov 23, 2016·The Journal of Cell Biology·Laura L Thomas, J Christopher Fromme
Aug 11, 2019·FEBS Letters·Zhanna Lipatova, Nava Segev
Feb 24, 2018·Frontiers in Cell and Developmental Biology·Yasuyuki SudaAkihiko Nakano
Mar 13, 2019·The Journal of Cell Biology·Jason C CaslerBenjamin S Glick
Mar 7, 2020·Current Opinion in Cell Biology·Laura L Thomas, J Christopher Fromme
Nov 6, 2021·The Journal of Cell Biology·Jason C CaslerBenjamin S Glick

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