Regulation of granulopoiesis and distribution of granulocytes in early phase of bacterial infection

Journal of Cellular Physiology
D W HartmannL True

Abstract

Studies have been carried out to determine the effect of bacterial infection on CSF production, CFU-C activation, and bacterial clearance by mature granulocytes in mice infected with Escherichia coli. These studies have shown that immediately after bacterial infection (5 minutes), serum colony-stimulating factor (CSF) levels and bone marrow colony-forming units in culture (CFU-C) levels are elevated. This is followed by oscillatory rises in both of these parameters and the appearance of granulocytes in the infected site. With clearance of bacteria, CSF and CFU-C levels return to normal. These studies have indicated further that bacterial infection is a major stimulus for granulocyte production through the CSF-CFU-C system and that clearance of bacteria by mature granulocytes may serve as a negative feedback regulatory arm.

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Citations

Jan 1, 1988·Annales De L'Institut Pasteur. Immunology·G Marchal, G Milon
Jul 28, 2010·Alcoholism, Clinical and Experimental Research·Caroline E RaaschGregory J Bagby
Jul 19, 2018·The Journal of Biological Chemistry·Keqiang ChenJi Ming Wang
Dec 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arielle Glatman ZaretskyChristopher A Hunter
Apr 20, 2018·American Journal of Reproductive Immunology : AJRI·Florian SchlieckauWolfgang Ernst
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ping ZhangSteve Nelson

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