PMID: 6401816Jan 1, 1983Paper

Regulation of granulopoiesis following severe thermal injury

The Journal of Trauma
V M PetersonW A Robinson

Abstract

Neutropenia often accompanies septicemia in burned patients. This paradox suggests a defect in the regulation of granulopoiesis. Colony stimulating factor (CSF) produced by the monocyte-macrophage system is an important regulator of granulocyte production. We followed serial serum CSF levels and peripheral blood leukocyte differential counts in 22 patients with greater than 30% burns. Six patients (mean burn, 58%) developed Gram-negative septicemia and died (Group I). Sixteen patients (mean burn, 38%) had no fatal septicemias (Group II). Nonsurvivors had initially low levels of CSF and developed persistent monocytopenia. Survivors, in contrast, had prompt rises in CSF and developed monocytosis. The presence of monocytopenia and low CSF levels in Group I suggests an abnormality in the stimulatory arm regulating granulopoiesis. Such a defect may play a role in the development of fatal septicemia following severe thermal injury.

Citations

Jun 1, 1992·Journal of Clinical Pharmacology·J M Rowe, A P Rapoport
Sep 25, 1999·Burns : Journal of the International Society for Burn Injuries·F W PeterH U Steinau
Mar 31, 2000·Burns : Journal of the International Society for Burn Injuries·M DeveciA Inal
Apr 1, 1988·Burns, Including Thermal Injury·R D ChristensenG Rothstein
Aug 1, 1985·The Journal of Surgical Research·J F HansbroughV Peterson
Nov 1, 1986·International Journal of Cell Cloning·V G IyengarW A Robinson
Oct 1, 1985·Burns, Including Thermal Injury·S F Wallner, G H Warren
Apr 1, 1984·Burns, Including Thermal Injury·S WallnerV Peterson
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·K D SilvaR Shankar
Aug 10, 2002·The Journal of Trauma·Richard GamelliElisabeth Hahn
Jun 5, 2004·The Journal of Trauma·José Gustavo ParreiraMaurício Rocha e Silva
Mar 20, 2016·Journal of Leukocyte Biology·Nicholas B JohnsonKuzhali Muthumalaiappan
Dec 31, 2002·The Journal of Surgical Research·Xiaosong SongDavid H Livingston
Dec 1, 1995·Current Problems in Surgery·C C Baker, M D Huynh

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