PMID: 8969886Nov 1, 1996Paper

Regulation of growth by ACTH in the Y-1 line of mouse adrenocortical cells

Endocrine Research
H A ArmelinA P Lepique

Abstract

Y-1 adrenal cells were cell cycle arrested by serum starvation to characterize a G0-->G1-->S transition in these cells. Cycle arrested Y-1 cells start to enter S phase 8h after serum feeding, reaching more than 90% cells synthesizing DNA by 24h. ACTH displays a dual effect in the G0-->G1-->S transition: 2h ACTH treatment stimulates DNA synthesis initiation, but longer treatments inhibit S phase entry. This dual effect of ACTH is similar to the antagonistic actions of PMA (phorbol-12-miristate-13-acetate) on the G0-->G1-->S transition. However ACTH and PMA are likely to have different mechanisms of action. ACTH inhibitory effect requires PKA, whereas PMA inhibitory effect is not dependent on PKA. ACTH induces the proto-oncogenes c-fos and c-jun, but inhibits the expression of the c-myc proto-oncogene. PMA, on the other hand, induces equally well c-fos, c-jun and c-myc. We hypothesize that ACTH promotes G0-->G1 transition by induction of c-fos and c-jun and blocks G1-->S transition by c-myc inhibition.

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Citations

Jun 20, 2003·Annals of the New York Academy of Sciences·Michelle L BlandHolly A Ingraham
Sep 27, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C F LotfiH A Armelin
Feb 13, 2001·Endocrine Reviews·A LacroixP Hamet
Jul 18, 2002·Annals of the New York Academy of Sciences·Lawrence S Kirschner
Jan 26, 2005·Endocrine Research·Erico T CostaHugo A Armelin
Aug 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H A Armelin, C F Lotfi
May 20, 2006·Anais Da Academia Brasileira De Ciências·Fábio L FortiHugo A Armelin
Jan 15, 1999·Endocrine Research·C F Lotfi, H A Armelin
Jan 15, 1999·Endocrine Research·F L Forti, H A Armelin
May 28, 2003·Microscopy Research and Technique·Kátia M RochaHugo A Armelin

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