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Regulation of hematopoietic stem cells by their mature progeny

Proceedings of the National Academy of Sciences of the United States of America

Dec 14, 2010

Carolyn A de GraafDouglas J Hilton

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Abstract

Thrombopoietin (TPO), acting through its receptor Mpl, has two major physiological roles: ensuring production of sufficient platelets via stimulation of megakaryocyte production and maintaining hematopoietic stem cell (HSC) quiescence. Mpl also controls circulating TPO concentration via...read more

Mentioned in this Paper

Thrombopoietin Measurement
Megakaryocytes
Mutant
Proto-Oncogene Proteins c-myb
EP300 wt Allele
EP300 gene
Ep300 protein, mouse
Thrombocytosis
Anatomical Compartments
Platelet Count Measurement
80
Paper Details
References
    • References34
    • Citations32
    • References34
    • Citations32
  • Regulation of hematopoietic stem cells by their mature progeny

    Proceedings of the National Academy of Sciences of the United States of America

    Dec 14, 2010

    Carolyn A de GraafDouglas J Hilton

    PMID: 21115812

    DOI: 10.1073/pnas.1016166108

    Abstract

    Thrombopoietin (TPO), acting through its receptor Mpl, has two major physiological roles: ensuring production of sufficient platelets via stimulation of megakaryocyte production and maintaining hematopoietic stem cell (HSC) quiescence. Mpl also controls circulating TPO concentration via...read more

    Mentioned in this Paper

    Thrombopoietin Measurement
    Megakaryocytes
    Mutant
    Proto-Oncogene Proteins c-myb
    EP300 wt Allele
    80
    Paper Details
    References
    • References34
    • Citations32
    • References34
    • Citations32
  • Get paper from

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