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Regulation of hematopoietic stem cells by their mature progeny

Proceedings of the National Academy of Sciences of the United States of America

Dec 1, 2010

Carolyn A de GraafDouglas J Hilton

Abstract

Thrombopoietin (TPO), acting through its receptor Mpl, has two major physiological roles: ensuring production of sufficient platelets via stimulation of megakaryocyte production and maintaining hematopoietic stem cell (HSC) quiescence. Mpl also controls circulating TPO concentration via...read more

Mentioned in this Paper

EP300 protein, human
Microarray Analysis
E1A-Associated p300 Protein
Colony-Forming Units, Hematopoietic
EP300 gene
Megakaryocytes
Thrombopoietin Receptor
Compartment of Cell
Cell Differentiation Process
Mice, Knockout
82
Paper Details
References
  • References34
  • Citations39
1234
  • References34
  • Citations39
1234

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Regulation of hematopoietic stem cells by their mature progeny

Proceedings of the National Academy of Sciences of the United States of America

Dec 1, 2010

Carolyn A de GraafDouglas J Hilton

PMID: 21115812

DOI: 10.1073/pnas.1016166108

Abstract

Thrombopoietin (TPO), acting through its receptor Mpl, has two major physiological roles: ensuring production of sufficient platelets via stimulation of megakaryocyte production and maintaining hematopoietic stem cell (HSC) quiescence. Mpl also controls circulating TPO concentration via...read more

Mentioned in this Paper

EP300 protein, human
Microarray Analysis
E1A-Associated p300 Protein
Colony-Forming Units, Hematopoietic
EP300 gene
Megakaryocytes
Thrombopoietin Receptor
Compartment of Cell
Cell Differentiation Process
Mice, Knockout
82

Similar Papers Found In These Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Hematopoetic Stem Cells

Hematopoietic stem cells (HSCs) are the cells that give rise to blood cells of the myeloid and lymphoid lineage during hematopoiesis. HSC transplantation is an established therapeutic option for both malignant and nonmalignant indications. Here is the latest research.

Paper Details
References
  • References34
  • Citations39
1234
  • References34
  • Citations39
1234
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