Regulation of hepatic carbohydrate metabolism by Selenium during diabetes

Chemico-biological Interactions
Hongping ChenJun Liang

Abstract

In the present study, we have tried to unravel the role of Selenium supplementation in containing hyperglycemia by regulating enzymes activities involved in carbohydrate metabolism in liver of diabetic animals. Male wistar rats were divided into four groups: normal control, diabetic, Selenium treated control and Selenium treated diabetic group. Diabetes was induced in the animals by injecting alloxan intraperitoneally at a dose level of 150 mg/kg body weight. Selenium in the form of sodium selenite was supplemented to rats at a dose level of 1 PPM in drinking water, ad libitum for two time durations of 2 and 4 weeks. Animals were sacrificed and livers were excised for the analyses of enzymes involved in carbohydrate metabolism as well as the levels of glycogen. In-vitro (14)C-d glucose uptake and its turnover were also assessed in liver slices of all the treatment groups using radiorespirometry. Selenium supplementation to the diabetic rats normalized the enzyme activities of glucose-6-phosphatase, lactate dehydrogenase and glycogen phosphorylase as well as restored the glycogen levels to within the normal limits which were altered during diabetes. Interestingly, when Selenium was supplemented to diabetic rats, (14)C-d glucose ...Continue Reading

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Citations

Dec 22, 2015·Biological Trace Element Research·Fereshteh BahmaniAhmad Esmaillzadeh
Feb 15, 2018·Oxidative Medicine and Cellular Longevity·Ning WangYibin Feng
May 28, 2019·Antioxidants·Athanasios C PappasStella E Chadio
Aug 23, 2021·Environmental Science and Pollution Research International·Ibrahim M AlhazzaMohamed Sheikh

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