Abstract
In the present study, we have tried to unravel the role of Selenium supplementation in containing hyperglycemia by regulating enzymes activities involved in carbohydrate metabolism in liver of diabetic animals. Male wistar rats were divided into four groups: normal control, diabetic, Selenium treated control and Selenium treated diabetic group. Diabetes was induced in the animals by injecting alloxan intraperitoneally at a dose level of 150 mg/kg body weight. Selenium in the form of sodium selenite was supplemented to rats at a dose level of 1 PPM in drinking water, ad libitum for two time durations of 2 and 4 weeks. Animals were sacrificed and livers were excised for the analyses of enzymes involved in carbohydrate metabolism as well as the levels of glycogen. In-vitro (14)C-d glucose uptake and its turnover were also assessed in liver slices of all the treatment groups using radiorespirometry. Selenium supplementation to the diabetic rats normalized the enzyme activities of glucose-6-phosphatase, lactate dehydrogenase and glycogen phosphorylase as well as restored the glycogen levels to within the normal limits which were altered during diabetes. Interestingly, when Selenium was supplemented to diabetic rats, (14)C-d glucose ...Continue Reading
References
Apr 7, 1978·Science·H F BunnP M Gallop
May 1, 1987·Diabetes·H HartmannW Creutzfeldt
Feb 1, 1985·Seminars in Liver Disease·B G Stone, D H Van Thiel
Apr 1, 1995·Journal of Diabetes and Its Complications·E BoelT Jensen
Nov 30, 1994·Biochemical and Biophysical Research Communications·Z LiuJ Y Chou
Aug 1, 1996·American Journal of Epidemiology·I J PerryK G Alberti
Sep 2, 1999·Carcinogenesis·H E Ganther
Mar 9, 2000·Diabetes/metabolism Research and Reviews·G WahlbergJ Svensson
Aug 19, 2000·Biological Trace Element Research·M MihailovićO Pesut
Jul 13, 2001·Journal of Ethnopharmacology·S N SinghK Sridharan
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Vijay K YechoorC Ronald Kahn
Dec 18, 1960·Biochimica Et Biophysica Acta·R K CRANE, P MANDELSTAM
Sep 30, 2003·Diabetes Care·Rachel DerrChristopher D Saudek
Oct 24, 2003·Free Radical Biology & Medicine·Levente József, János G Filep
Feb 11, 1949·Science·E Kun, L G Abood
May 14, 2009·JAMA : the Journal of the American Medical Association·Margaret P RaymanDavid J Waters
Mar 11, 2010·Toxicologic Pathology·Eike FloettmannHuw B Jones
Oct 15, 2009·World Journal of Gastrointestinal Oncology·Fereshteh Ezzati GhadiDevinder Kumar Dhawan
Nov 10, 2012·Journal of Gastrointestinal Cancer·Fereshteh Ezzati GhadiD K Dhawan
Apr 8, 2014·PloS One·Anshoo MalhotraDevinder Kumar Dhawan
Citations
Mar 6, 2016·Chemico-biological Interactions·Subramani Srinivasan, Udaiyar Muruganathan
Dec 22, 2015·Biological Trace Element Research·Fereshteh BahmaniAhmad Esmaillzadeh
Oct 7, 2015·The British Journal of Nutrition·Maryam KaramaliZatollah Asemi
Feb 15, 2018·Oxidative Medicine and Cellular Longevity·Ning WangYibin Feng
Dec 9, 2016·Biological Trace Element Research·Elaheh MesdaghiniaZatollah Asemi
May 28, 2019·Antioxidants·Athanasios C PappasStella E Chadio
Aug 23, 2021·Environmental Science and Pollution Research International·Ibrahim M AlhazzaMohamed Sheikh