Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia.

Biochimica Et Biophysica Acta
Laure PeytaStephane Servais

Abstract

Cardiolipin (CL) content accumulation leads to an increase in energy wasting in liver mitochondria in a rat model of cancer cachexia in which tumor necrosis factor alpha (TNFα) is highly expressed. In this study we investigated the mechanisms involved in liver mitochondria CL accumulation in cancer cachexia and examined if TNFα was involved in this process leading to mitochondrial bioenergetics alterations. We studied gene, protein expression and activity of the main enzymes involved in CL metabolism in liver mitochondria from a rat model of cancer cachexia and in HepaRG hepatocyte-like cells exposed to 20 ng/ml of TNFα for 12 h. Phosphatidylglycerolphosphate synthase (PGPS) gene expression was increased 2.3-fold (p<0.02) and cardiolipin synthase (CLS) activity decreased 44% (p<0.03) in cachectic rat livers compared to controls. CL remodeling enzymes monolysocardiolipin acyltransferase (MLCL AT-1) activity and tafazzin (TAZ) gene expression were increased 30% (p<0.01) and 50% (p<0.02), respectively, in cachectic rat livers compared to controls. Incubation of hepatocytes with TNFα increased CL content 15% (p<0.05), mitochondrial oxygen consumption 33% (p<0.05), PGPS gene expression 44% (p<0.05) and MLCL AT-1 activity 20% (p<0.05...Continue Reading

References

Nov 1, 1992·Annals of Surgery·J StadlerR L Simmons
Oct 1, 1980·Canadian Journal of Biochemistry·W C McMurray, E C Jarvis
Apr 1, 1996·Nature Genetics·S BioneD Toniolo
Oct 18, 1996·The Journal of Biological Chemistry·G M Hatch, G McClarty
Nov 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Philippe GriponChristiane Guguen-Guillouzo
Feb 6, 2003·The Journal of Biological Chemistry·William A Taylor, Grant M Hatch
Aug 30, 2003·Cytokine·Sílvia BusquetsJosep M Argilés
Jul 1, 1964·Biochemistry·J LECOCQ, C E BALLOU
Nov 3, 2005·Nature Clinical Practice. Oncology·Alessandro LavianoFilippo Rossi-Fanelli
Mar 21, 2006·Journal of Lipid Research·Biao LuKenneth R Feingold
Aug 19, 2007·American Journal of Physiology. Endocrinology and Metabolism·Matthieu ArvierPatrick Ritz
Sep 10, 2009·The Journal of Biological Chemistry·William A Taylor, Grant M Hatch
Apr 2, 2010·Nutrition and Cancer·Jean-François DumasCharles Couet
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Mar 19, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Carla M M PradoVickie E Baracos
Jun 7, 2011·Cell Metabolism·Ji ZhangJack E Dixon
Jun 13, 2012·The International Journal of Biochemistry & Cell Biology·Beata DrabarekKrzysztof Zabłocki
Mar 28, 2013·PloS One·Yuan-Hao HsuEdward A Dennis
Nov 5, 2013·Biochimica Et Biophysica Acta·Giuseppe ParadiesGiuseppe Petrosillo
Nov 5, 2013·Chemistry and Physics of Lipids·Matthew G BaileSteven M Claypool
Apr 29, 2014·Progress in Lipid Research·Mindong RenMichael Schlame
May 8, 2014·Cardiovascular & Hematological Disorders Drug Targets·Edgard M MejiaGrant M Hatch
May 31, 2014·BioMed Research International·Jill K Onesti, Denis C Guttridge

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Citations

Aug 25, 2017·Antioxidants & Redox Signaling·Yulia Y TyurinaValerian E Kagan
Nov 23, 2018·Nature Reviews. Endocrinology·Josep M ArgilésSilvia Busquets
Apr 2, 2020·International Journal of Molecular Sciences·Guilherme Wesley Peixoto da FonsecaMitja Lainscak
Mar 21, 2019·EMBO Reports·Maria RohmStephan Herzig
Nov 1, 2020·International Journal of Molecular Sciences·Seyedeh Tayebeh AhmadpourJean-François Dumas
Mar 31, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Jawed A SiddiquiMohd W Nasser
Oct 21, 2020·Cancer Letters·Zhangxiao PengChangqing Su
Jul 31, 2021·The British Journal of Nutrition·Yi-Zhong GeHan-Ping Shi
Aug 28, 2021·Life·Julia Windi GunadiRonny Lesmana

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