Regulation of hepatic fatty acid synthetase in the obese-hyperglycemic mutant mouse.

Biochimica Et Biophysica Acta
J J Volpe, J C Marasa

Abstract

Regulation of fatty acid synthetase has been studied in the obese-hyperglycemic mouse and compared with regulation in non obese, littermate control animals. The mechanisms underlying the regulatory changes were defined by immunochemical techniques. Several major conclusions are justified from the data obtained: (1) Although the hepatic specific activity of fatty acid synthetase is higher in obese than in non obese animals pair-fed chow, no difference in hepatic activities is apparent in animals pair-fed the fat-free diet; (2) The higher enzymatic activity in obese animals fed chow is related to a higher content of enzyme, and this higher content is associated with a higher rate of enzyme synthesis; (3) The decrease in hepatic synthetase activity with starvation is distinctly more striking in non obese than in obese animals, and the changes in activity reflect changes in content of enzyme; (4) With starvation there is a decrease in synthesis of enzyme in obese and non obese animals, but only in non obese animals is there also a marked increase in the rate of synthetase degradation (t1/2 = 24 h during starvation, t1/2 = 76 h during normalfeeding); (5) Refeeding starved mice a fat-free diet results in a more striking increase in h...Continue Reading

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Citations

Jan 1, 1978·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D A YorkT G Taylor
Mar 17, 2004·The Journal of Nutritional Biochemistry·Ian J Martins, Trevor G Redgrave
Jan 1, 2009·Animal : an International Journal of Animal Bioscience·K J HarvatineD E Bauman
Nov 29, 2011·Journal of Dairy Science·K J Harvatine, D E Bauman

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