PMID: 3215855Dec 1, 1988Paper

Regulation of hepatic glucose production in running rats studied by glucose infusion

Journal of Applied Physiology
J VissingH Galbo

Abstract

The importance of metabolic feedback regulation vs. feedforward regulation of hepatic glucose production (HGP) during exercise was investigated in rats by infusing glucose intravenously from the onset of running. Glucose infusion equaled the average exercise-induced increase from basal to steady state in HGP found in saline-infused control rats. Rats were studied at two work loads, running at 21 (series I) or 18 m/min (series II) for 35 min. Glucose turnover was measured by means of an intravenous [3H]glucose infusion. HGP was suppressed by glucose infusion corresponding to the infused amount of glucose in both series, except for late in exercise in series I, where HGP plus infused glucose tended to exceed HGP in saline-infused rats (P less than 0.10). Muscle glycogenolysis and fat metabolism were similar in both groups in the two series. Plasma glucose was never elevated, whereas insulin was, in glucose- vs. saline-infused rats of both series. Plasma catecholamines were lower in glucose- compared with saline-infused rats in series II. In conclusion, HGP is very sensitive to metabolic feedback inhibition at low exercise intensities. Feedforward control of HGP may play a role at higher work loads (series I). Exogenously supplied...Continue Reading

Citations

May 9, 1998·Journal of Applied Physiology·K HowlettM Hargreaves
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·S H KreismanE B Marliss
Mar 1, 1994·Pflügers Archiv : European journal of physiology·J A HawleyT D Noakes
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·S H KreismanE B Marliss

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