Regulation of hepatic synthesis of C3 and C4 during the acute-phase response in the rat

European Journal of Immunology
R AnthonyK Whaley

Abstract

Following the i.p. injection of casein, rats showed increased serum levels of C4 and C3. C4 levels peaked on day 2 and returned to normal by day 4, while C3 levels peaked on day 3 before returning to normal on day 4. These changes were paralleled by changes in the hepatocyte synthesis rates of these two proteins. Macrophages, isolated from the peritoneal cavities of rats on days 1 to 7 (day-1 to day-7 macrophages) following i.p. injection of casein, were cultured in vitro, and the peritoneal macrophage-conditioned media (PMCM) assayed for their abilities to stimulate synthesis of C4 and C3 by hepatocytes from control rats. Day-2 PMCM selectively stimulated synthesis of C4, while day-3 and day-4 PMCM selectively stimulated C3 synthesis. These activities were called C4-hepatocyte stimulating factor (C4-HSF) and C3-HSF, respectively. The addition of anti-interleukin (IL) 1, tumor necrosis factor (TNF)-alpha, TNF-beta, IL 6 or interferon (IFN)-gamma antibodies to day-2 PMCM did not affect C4-HSF activity, and none had any effect on C3-HSF activity in day-4 PMCM. However, the addition of anti-IL 1 to day-4 PMCM resulted in the re-expression of C4-HSF activity as well as loss of thymocyte proliferative activity. C4-HSF activity could...Continue Reading

References

Nov 1, 1986·The Journal of Clinical Investigation·D H PerlmutterH R Colten
Oct 24, 1986·Science·K J TraceyJ D Albert
Nov 15, 1985·The Biochemical Journal·R AnthonyK Whaley
Feb 15, 1985·The Biochemical Journal·A C Yeung LaiwahK Whaley
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Jan 1, 1984·Reviews of Infectious Diseases·C A Dinarello
Jan 1, 1982·Annals of the New York Academy of Sciences·I Kushner

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Citations

Jan 1, 1993·Immunologic Research·A R McPhaden, K Whaley
Apr 26, 2013·Immunologic Research·Eleonora BallantiRoberto Perricone
Sep 1, 1992·Immunopharmacology·K WhaleyD Lappin
Dec 4, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jeffrey DammanMarc A Seelen
May 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·S MeijssenM Castro Cabezas

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