Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

Trends in Biochemical Sciences
Rafael FrancoE I Canela

Abstract

G-protein-coupled receptors form homomers and heteromers; agonist-induced conformational changes within interacting receptors of the oligomer modify their pharmacology, signalling and/or trafficking. When these receptors are activated, the oligomers rearrange and cluster and a novel mechanism of receptor-operation regulation by oligomer intercommunication is possible. This intercommunication would be assisted by components of the plasma membrane and by scaffolding proteins. Receptor cross-sensitization, cross-desensitization and novel, integrated receptor responses can then develop between oligomeric receptor complexes of the cluster without direct contact between them. This concept gives a new perspective to the understanding of neurotransmission and neuronal plasticity.

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Citations

Feb 4, 2005·Neurourology and Urodynamics·Sandra SigalaGiovanni Muzzonigro
Feb 14, 2009·Journal of Computer-aided Molecular Design·Xin LiuRui Wang
Jul 1, 2008·Nature Methods·Paulina CarribaRafael Franco
Aug 9, 2007·BMC Bioinformatics·Gul S DalginGyan Bhanot
Sep 30, 2006·Journal of Computer-aided Molecular Design·Francesca Fanelli, Pier G De Benedetti
Aug 12, 2009·Pharmacology & Therapeutics·Vicent CasadóEnric I Canela
Jul 16, 2008·Brain Research Reviews·Rafael FrancoCarme Lluis
Aug 13, 2013·Microscopy Research and Technique·Antonio TrulloMoreno Zamai
May 6, 2009·British Journal of Pharmacology·Carla FerradaRafael Franco
Nov 27, 2007·British Journal of Pharmacology·R FrancoE I Canela
Apr 1, 2010·Expert Opinion on Drug Discovery·Rafael FrancoSergi Ferre
Aug 20, 2010·Journal of Receptor and Signal Transduction Research·Francisco CiruelaVíctor Fernández-Dueñas
Oct 21, 2006·Molecular and Cellular Endocrinology·F Fanelli
Sep 12, 2009·Atencion primaria·Rafael Franco
Aug 19, 2007·Trends in Neurosciences·Sergi FerréRafael Franco
Jun 17, 2004·The Journal of Biological Chemistry·Yoshikazu SuzukiHisato Jingami
Mar 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paulina CarribaSergi Ferré
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Feb 28, 2006·Molecular Pharmacology·Rafael FrancoEnric I Canela
Oct 21, 2003·The Journal of Pharmacology and Experimental Therapeutics·Timothy A Vortherms, Val J Watts
Apr 4, 2021·International Journal of Molecular Sciences·Mireia CasanovasRafael Franco
Jun 14, 2005·Trends in Biochemical Sciences·Rafael FrancoEnric I Canela

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