Regulation of hexitol catabolism in Streptococcus mutans.

Journal of Bacteriology
S S Dills, S Seno

Abstract

Regulation of hexitol catabolism was investigated in Streptococcus mutans, a cariogenic human dental plaque bacterium. Induction of hexitol catabolic enzymes and phosphoenolpyruvate:hexitol phosphotransferase and hexitol phosphate dehydrogenase activities was regulated by an inducer exclusion mechanism initiated by D-glucose and 2-deoxy-D-glucose. Kinetic analysis of the inhibitory effect of 2-deoxy-D-glucose on initial hexitol uptake illustrated that this was a noncompetitive type of inhibition. In mutant strains of S. mutans lacking phosphoenolpyruvate:glucose phosphotransferase activity, 2-deoxy-D-glucose was unable to inhibit hexitol uptake. These observations provide evidence for possible molecular mechanisms for the exclusion process.

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Citations

Jun 1, 1991·Oral Microbiology and Immunology·I R Hamilton, G Svensater
Sep 22, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Danielle Duanis-AssafMoshe Shemesh
Jun 1, 1991·Oral Microbiology and Immunology·G Svensater, I R Hamilton
Oct 1, 1990·Oral Microbiology and Immunology·S BourassaC Vadeboncoeur
Feb 28, 2002·Oral Microbiology and Immunology·C K Cote, Allen L Honeyman
Jun 1, 1992·Oral Microbiology and Immunology·G SvensäterS Kalfas
Mar 1, 1987·Journal of Cellular Biochemistry·C S MimuraG R Jacobson
Apr 1, 1994·Infection and Immunity·D L Kiska, F L Macrina
Sep 1, 1985·Microbiological Reviews·P W Postma, J W Lengeler
Sep 1, 1985·Microbiological Reviews·D K Button
Sep 1, 1993·Microbiological Reviews·P W PostmaG R Jacobson

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