Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2

Nature Structural & Molecular Biology
Chunyuan JinKazunari K Yokoyama

Abstract

Jun dimerization protein-2 (JDP2) is a component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Here, we examine the functional mechanisms of JDP2 and show that it can inhibit p300-mediated acetylation of core histones in vitro and in vivo. Inhibition of histone acetylation requires the N-terminal 35 residues and the DNA-binding region of JDP2. In addition, we demonstrate that JDP2 has histone-chaperone activity in vitro. These results suggest that the sequence-specific DNA-binding protein JDP2 may control transcription via direct regulation of the modification of histones and the assembly of chromatin.

References

Jan 1, 1991·Methods in Enzymology·J A Wells
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·J E Brownell, C D Allis
Jun 1, 1997·Molecular and Cellular Biology·A AronheimM Karin
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J D WeissmanD S Singer
Jan 19, 2000·Nature·B D Strahl, C D Allis
Jan 29, 2000·Molecular and Cellular Biology·J G MoggsG Almouzni
Apr 12, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T MunakataM Horikoshi
Oct 5, 2001·The Journal of Biological Chemistry·A M MakowskiA T Annunziato
Feb 22, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takashi UmeharaMasami Horikoshi
Jul 9, 2002·Molecular and Cellular Biology·Suzanne E WardellDean P Edwards
Aug 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Harry C HwangBruce E Clurman
Nov 7, 2002·Cell·Bryan M Turner
Jun 13, 2003·Trends in Genetics : TIG·Michael J CarrozzaJacques Côté
Nov 25, 2003·The Journal of Biological Chemistry·Ronit HeinrichAmi Aronheim
Jul 19, 2005·Molecular and Cellular Biology·Mikko TaipaleAsifa Akhtar

❮ Previous
Next ❯

Citations

Apr 27, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhe LiuYuanhong Xu
Apr 28, 2007·Cell Death and Differentiation·K NakadeK K Yokoyama
Apr 29, 2011·The Journal of Biological Chemistry·Takayuki MurataTatsuya Tsurumi
Feb 24, 2009·The Journal of Biological Chemistry·Koji NakadeKazunari K Yokoyama
May 9, 2008·Nucleic Acids Research·Keren Weidenfeld-BaranboimAmi Aronheim
Jan 5, 2011·Journal of Biomedicine & Biotechnology·Yu-Chang HuangKazunari K Yokoyama
Apr 9, 2008·FEBS Letters·Yoan ChérasseAlain Bruhat
Jul 11, 2007·The Journal of Cell Biology·Shaogang SunChen Wang
Oct 19, 2010·The Kaohsiung Journal of Medical Sciences·Yu-Chang HuangKazunari Kzaushige Yokoyama
May 7, 2010·Trends in Biochemical Sciences·Chandrima DasMair E A Churchill
May 15, 2009·Journal of Cellular and Molecular Medicine·Arun K MankanRoss McManus
May 6, 2009·BioFactors·Alain BruhatPierre Fafournoux
Aug 5, 2015·Cell Stress & Chaperones·Liang SunCarl J Schmidt
Jul 5, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kenta Maruyama, Shizuo Akira
Apr 5, 2016·Gene·Ming-Ho TsaiKazunari K Yokoyama
Aug 2, 2011·Molecular and Cellular Endocrinology·Krista K HillDean P Edwards
May 24, 2016·The Journal of Clinical Investigation·Elisa LentiAndrea Brendolan
Feb 2, 2017·International Journal of Molecular Sciences·Chiung-Min WangWei-Hsiung Yang
Sep 28, 2016·Molecular and Cellular Biology·Lei FangChunyuan Jin
Oct 8, 2016·Nature Communications·June BaikRita C R Perlingeiro
Dec 6, 2018·Endocrinology·George A StamatiadesUrsula B Kaiser
May 1, 2010·Biomolecular Concepts·Koji NakadeKazunari K Yokoyama
Oct 27, 2015·Oncotarget·Yelena BarbarovAmi Aronheim
May 18, 2018·Scientific Reports·Jacqueline HegerGerhild Euler
Mar 17, 2021·Cell Biology and Toxicology·Kenly WuputraKazunari K Yokoyama
May 1, 2021·International Journal of Molecular Sciences·Gerhild EulerMariana S Parahuleva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.